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Sucksmith, E.; Roth, I. and
(2011).
DOI: https://doi.org/10.1007/s11065-011-9183-9
Abstract
Diagnosis, intervention and support for people with autism can be assisted by research into the aetiology of the condition. Twin and family studies indicate that autism spectrum conditions are highly heritable; genetic relatives of people with autism often show milder expression of traits characteristic for autism, referred to as the Broader Autism Phenotype (BAP). In the past decade, advances in the biological and behavioural sciences have facilitated a more thorough examination of the BAP from multiple levels of analysis. Here, the candidate phenotypic traits delineating the BAP are summarised, including key findings from neuroimaging studies examining the neural substrates of the BAP. We conclude by reviewing the value of further research into the BAP, with an emphasis on deriving heritable endophenotypes which will reliably index autism susceptibility and offer neurodevelopmental mechanisms that bridge the gap between genes and a clinical autism diagnosis.
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About
- Item ORO ID
- 29858
- Item Type
- Journal Item
- ISSN
- 1573-6660
- Keywords
- autism; broader autism phenotype; social cognition; phenotypic heterogeneity; endophenotypes
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Research Group
- Neuroscience Research Group
- Copyright Holders
- © 2011 Springer Science+Business Media, LLC
- Depositing User
- Rosa Hoekstra