NMR and UV studies of 4-Thio-2′-deoxyuridine and its derivatives

Zhang, Xiaohui and Xu, Yao-Zhong (2011). NMR and UV studies of 4-Thio-2′-deoxyuridine and its derivatives. Molecules, 16(7) pp. 5655–5664.

DOI: https://doi.org/10.3390/molecules16075655

Abstract

5-Substituted-4-thio-2’-deoxyuridine nucleosides have been chemically synthesized and studied by NMR and UV spectroscopy. The results have been analyzed and discussed in connection with the previous data. The imino proton signal and the carbon signal of the thiocarbonyl group in the 5-substituted-4-thio-2’-deoxyuridines were found to be at much lower field, offering a potential for monitoring these modified bases at the DNA level. All 4-thionucleosides have strong absorptions at around 340 nm and consequently would be useful as potential UVA-induced anticancer agents.

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About

• Item ORO ID
• 29051
• Item Type
• Journal Item
• ISSN
• 1420-3049
• Project Funding Details

• Funded Project Name	Project ID	Funding Body
  Not Set	Not Set	The Open University, UK
  Not Set	Not Set	the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, China

• Keywords
• NMR; UV; 4-thiothymidine; DNA
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © 2011 The Authors
• Depositing User
• Yao Xu