Radiolabelled Aptamers for Imaging and Therapy

Missailidis, Sotiris and Perkins, Alan (2011). Radiolabelled Aptamers for Imaging and Therapy. In: Speer, Tod ed. Targeted Radionuclide Therapy. Lippincott Williams & Wilkins, pp. 59–68.

URL: http://www.lww.com/product/Targeted-Radionuclide-T...

Abstract

[About the book]

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion.

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