Regional expression of synaptic markers in Creutzfeldt-Jakob disease (platform presentation)

Harry-Olatoke, R.; Khan, M.N.; Al-Sarraj, S.; Lantos, P.L.; Anderton, B. and Rezaie, P. (2004). Regional expression of synaptic markers in Creutzfeldt-Jakob disease (platform presentation). In: 105th Meeting of the British Neuropathological Society, 07-09 Jan 2004, Institute of Child Health, London.

Abstract

Cellular prion protein (PrPe) is a membrane-bound glycoprotein, reportedly expressed at high levels at synapses. The function of PrPe is uncertain. However, the formation of an abnormal isoform (PrPSe) is considered central to the pathogenesis of Creutzfeldt-Jakob disease (CJD), and synaptic damage has been suggested as an early pathological event in CJD.

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