Development of anti MUC1 DNA aptamers for the imaging and radiotherapy of breast cancer

Da Pieve, C.; Iley, J. N.; Perkins, A. and Missailidis, S. (2006). Development of anti MUC1 DNA aptamers for the imaging and radiotherapy of breast cancer. Breast Cancer Research, 8 pp. 15–16.

DOI: https://doi.org/10.1186/bcr1587

URL: http://www.springerlink.com/content/y517l64447ml85...

Abstract

Aptamers are novel oligonucleotide-based recognition molecules which can bind to almost any target, including extracellular proteins, antibodies, peptides and small molecules. Aptamers can be rapidly generated, and offer reduced immunogenicity, good tumour penetration, rapid uptake and clearance, and can thus be used as alternatives to monoclonal antibodies in molecular targeted radiotherapy and diagnostic imaging.

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