Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents

Diniz, Claudia Leite; Santos Do Carmo, Fernanda; Santos de Almeida, Danielle; Missailidis, Sotiris; Santos-Filho, Sebastião David; de Souza da Fonseca, Adenilson and Bernardo-Filho, Mario (2008). Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents. Brazilian Archives of Biology and Technology, 51 pp. 215–219.

DOI: https://doi.org/10.1590/S1516-89132008000700035

Abstract

This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na^99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract and, 1 hour after, Na^99mTcO4 was administered; organs/tissues were withdrawn and weighted. The radioactivity was counted to calculate the percentage of activity per gram (%ATI/g). Also, blood samples were withdrawn, plasma (P), blood cells (BC), insoluble fraction (IF) and soluble fractions of P and BC were isolated and the radioactivity was counted to calculate the percentage of activity (%ATI). Data indicated that the acute treatment with CA extract changed significantly (p<0.05) the %ATI/g in several organs/tissues (spleen, heart, duodenum, stomach, liver, muscle, kidney, testis and blood) and the %ATI on the blood constituents (P, BC, IF-P and IF-BC). These results indicate that the substances or metabolites of the CA extract would change the biodistribution of Na^99mTcO4 and the fixation of the technetium-99m on blood constituents in an acute treatment.

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About

• Item ORO ID
• 26052
• Item Type
• Journal Item
• ISSN
• 1516-8913
• Extra Information
• Published in special issue of this volume of this journal
• Keywords
• biodistribution; Centella asiatica; blood; plasma; Technetium-99m
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © Brazilian Archives of Biology and Technology
• Depositing User
• Sotiris Missailidis