Development and characterisation of aptamers as inhibitors of vital pathways in cancer therapy

Khan, Huma; Makwana, Vaidehi; Courtenay-Luck, Nigel and Missailidis, Sotiris (2008). Development and characterisation of aptamers as inhibitors of vital pathways in cancer therapy. Anticancer Research, 28(5C) pp. 3346–3347.

URL: http://ar.iiarjournals.org/content/28/5C

Abstract

Aptamers can be described as short oligonucleotides that harbour great potential in their versatile applications, due to their high affinity and specificity for their target of choice. Despite their infancy, aptamers have already emerged at the forefront of clinical research, offering significant contribution as therapeutic agents for a range of diseases. Thus, our research is aimed towards generating aptamer(s) for a specific cancer biomarker that, when blocked, can lead to specific cell kill and thus offer a novel therapeutic potential against cancer.

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