Meningococcal vaccine trials

Farrington, Paddy and Miller, Elizabeth (2001). Meningococcal vaccine trials. In: Pollard, Andrew J. and Maiden, Martin C. J. eds. Meningococcal Vaccines: Methods and Protocols. Methods in Molecular Biology (66). Totowa, New Jersey, USA: Humana Press, pp. 371–393.




The evaluation of meningococcal vaccines in humans is a challenging task. Issues of safety, and benefit to the individual patient and to the community may raise difficult ethical problems. The inherent variability of human responses, the rarity of clinical disease, age-dependence in the immune response, and the role of carriers complicates the evaluation process.

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