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Whitaker, Heather J.; Hocine, Mounia N. and Farrington, C. Paddy
(2009).
DOI: https://doi.org/10.1177/0962280208092342
Abstract
The self-controlled case series method is increasingly being used in pharmacoepidemiology, particularly in vaccine safety studies. This method is typically used to evaluate the association between a transient exposure and an acute event, using only cases. We present both parametric and semiparametric models using a motivating example on MMR vaccine and bleeding disorders. We briefly describe approaches for interferent events and a sequential version of the method for prospective surveillance of drug safety. The efficiency of the self-controlled case series method is compared to the that of cohort and case control studies. Some further extensions, to long or indefinite exposures and to bivariate counts, are described.
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About
- Item ORO ID
- 22512
- Item Type
- Journal Item
- ISSN
- 1477-0334
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Mathematics and Statistics
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Copyright Holders
- © 2009 SAGE Publications
- Depositing User
- Sarah Frain