Control without separate controls: evaluation of vaccine safety using case-only methods

Farrington, C. P. (2004). Control without separate controls: evaluation of vaccine safety using case-only methods. Vaccine, 22(15-16) pp. 2064–2070.

DOI: https://doi.org/10.1016/j.vaccine.2004.01.017

Abstract

Epidemiological methods involving only cases are reviewed in the context of vaccine safety studies. These methods include some ecological methods, case-coverage methods, case-crossover and self-controlled case series methods. The properties of the methods are described using examples from the literature. It is argued that such methods, and in particular the self-controlled case series method, are powerful epidemiologic tools meriting the same attention as more traditional cohort and case–control methods.

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