Hydropyrolysis as a preparative method for the compound-specific carbon isotope analysis of fatty acids

Sephton, M. A.; Meredith, W.; Sun, C. G. and Snape, C. E. (2005). Hydropyrolysis as a preparative method for the compound-specific carbon isotope analysis of fatty acids. Rapid Communications in Mass Spectrometry, 19(3) pp. 323–325.

DOI: https://doi.org/10.1002/rcm.1788

Abstract

Compound-specific stable carbon isotope analysis by gas chromatography/combustion/isotope ratio mass spectrometry is an effective and risk-free means of investigating fatty acid metabolism. Straightforward analysis, however, leads to poor chromatographic resolution, while derivatization adds carbon thereby corrupting the starting stable isotopic composition. Hydropyrolysis is a new approach which defunctionalizes fatty acids to yield the corresponding n-alkanes thus retaining the carbon skeleton intact and improving chromatography, allowing the faithful measurement of carbon isotope ratios. Copyright (C) 2005 John Wiley Sons, Ltd.

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