Characterising regional ultrastructure in peripheral nerves

Mason, S.; Harle, J. and Phillips, J. B. (2009). Characterising regional ultrastructure in peripheral nerves. In: European Cells and Materials, 18(Sup 2) p. 77.



Peripheral nerve repair is often compromised by a failure to restore the biomechanical integrity of damaged nerves. Restoration of the tensile properties of nerves, in particular their ability to bend and stretch during limb movement, is an important consideration in the design of tissue engineered repair conduits and other repair approaches. An understanding of the mechanical architecture of peripheral nerves that underpins their tensile properties is therefore desirable. Previous research has identified that the stiffness of rat peripheral nerves varies longitudinally according to where they traverse joints. This study explores how ultrastructural features such as the size-distribution of collagen fibrils and the thickness of the perineurium vary in specific regions of rat sciatic nerves.

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