Monitoring vaccine safety using case series cumulative sum charts

Musonda, Patrick; Hocine, Mounia N.; Andrews, Nick J.; Tubert-Bitter, Pascale and Farrington, Paddy C. (2008). Monitoring vaccine safety using case series cumulative sum charts. Vaccine, 26(42) pp. 5358–5367.

DOI: https://doi.org/10.1016/j.vaccine.2008.08.010

Abstract

We adapt the self-controlled case series method for routine surveillance of vaccine safety using cumulative sum (CUSUM) charts. The CUSUM surveillance method we propose is applicable for detecting associations that arise in a short pre-determined risk period following vaccination. The performance of the case series CUSUM is investigated through simulations. We illustrate the method using retrospective analyses of influenza vaccine and Bell's palsy, and MMR vaccine and febrile convulsions.

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About

• Item ORO ID
• 15751
• Item Type
• Journal Item
• ISSN
• 0264-410X
• Project Funding Details

• Funded Project Name	Project ID	Funding Body
  Not Set	Not Set	MRC (Medical Research Council)
  Not Set	Not Set	EPSRC (Engineering and Physical Sciences Research Council)
  Not Set	Not Set	Fondation pour la Recherche Médicale

• Keywords
• adverse event; self-controlled case series method; CUSUM; average run length; surveillance; vaccine
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Mathematics and Statistics
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © 2008 Elsevier Ltd.
• Depositing User
• Colin Smith