Currently browsing: Items authored or edited by James Iley

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Jones, Raymond C. F.; Choudhury, Abdul K.; Iley, James N.; Loizou, Georgia; Lumley, Christopher and McKee, Vickie (2010). New methodologies for the synthesis of 3-acylpyridone metabolites. Synlett(4) pp. 654–658.

Santos, Maria M.M.; Faria, Natália; Iley, Jim; Coles, Simon J.; Hursthouse, Michael B.; Martins, M. Luz and Moreira, Rui (2010). Reaction of Naphthoquinones with Substituted Nitromethanes. Facile Synthesis and antifungal activity of Naphtho[2,3-d]isoxazole-4,9-diones. Bioorganic and Medicinal Chemistry Letters, 20(1) pp. 193–195.

Mulchande, Jalmira; Oliveira, Rudi; Carrasco, Marta; Gouveia, Luís; Guedes, Rita C.; Iley, Jim and Moreira, Rui (2010). 4-Oxo-β-lactams (Azetidine-2,4-diones) Are Potent and Selective Inhibitors of Human Leukocyte Elastase. Journal of Medicinal Chemistry, 53(1) pp. 241–253.

Alcaro, Stefano; Artese, Anna; Iley, James N.; Missailidis, Sotiris; Ortuso, Francesco; Parrotta, Lucia; Pasceri, Raffaele; Paduano, Francesco; Sissi, Claudia; Trapasso, Francesco and Vigorita, Maria Gabriella (2010). Rational design, synthesis, biophysical and antiproliferative evaluation of fluorenone derivatives with DNA G-quadruplex binding properties. ChemMedChem, 5(4) pp. 575–583.

2009To Top

Jones, Raymond C.F.; Iley, James N.; Sanchis-Amat, Maria; Zhan, Xiaohui and Elsegood, Mark R.J. (2009). A catalytic dipolar cycloaddition route to pyrroloimidazoles. Tetrahedron Letters, 50(26) pp. 3577–3579.

Jones, Raymond C.F.; Yau, Sze Chak; Iley, James N.; Smith, Janet E.; Dickson, James; Elsegood, Mark R.J.; McKee, Vickie and Coles, Simon J. (2009). Synthesis of the Pyoverdin Chromophore by a Biomimetic Oxidative Cyclization. Organic Letters, 11(7) pp. 1519–1522.

Perry, Maria de Jesus; Carvalho, Emília; Rosa, Eduarda and Iley, Jim (2009). Towards an efficient prodrug of the alkylating metabolite monomethyltriazene: Synthesis and stability of N-acylamino acid derivatives of triazenes. European Journal of Medicinal Chemistry, 44(3) pp. 1049–1056.

Perry, M. J.; Mendes, E.; Simplício, A. L.; Coelho, A.; Iley, J.; Moreira, R. and Francisco, A. P. (2009). Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design. European Journal of Medicinal Chemistry, 44(8) pp. 3228–3234.

Simmons, Suzanne; Brenchley, P. E. C.; Iley, James; McKenzie, E. A.; Velasco, Maria and Missailidis, Sotiris (2009). Anti-heparanase aptamers as inhibitors of angiogenesis and tissue remodelling. In: YSL Networking Angiogenesis Conference, 14 Jul 2009.

2008To Top

Rodrigues, Tiago; Moreira, Rui; Guedes, Rita C.; Iley, Jim and Lopes, Francisca (2008). Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design. Archiv der Pharmazie, 341(6) pp. 344–350.

Mulchande, J.; Guedes, R. C.; Tsang, W.-Y.; Page, M. I.; Moreira, R. and Iley, J. (2008). Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors. Journal of Medicinal Chemistry, 51(6) pp. 1783–1790.

2007To Top

Moreira, Rui; Valente, Claudia; Guedes, Rita C.; Iley, Jim; Jaffar, Mohammed and Douglas, Kenneth T. (2007). The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors. Bioorganic and Medicinal Chemistry, 15(15) pp. 5340–5350.

Alcaro, Stefano; Artese, Anna; Iley, James N.; Maccari, Rosanna; Missailidis, Sotiris; Ortuso, Francesco; Ottana, Rosaria; Ragazzon, Patricia and Vigorita, Maria Gabriella (2007). Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold. Bioorganic and Medicinal Chemistry Letters, 17(9) pp. 2509–2514.

Oliveira, Tânia F.; Mulchande, Jalmira; Moreira, Rui; Iley, Jim and Archer, Margarida (2007). Crystallization and Preliminary Diffraction Studies of Porcine Pancreatic Elastase in Complex with a Novel Inhibitor. Protein and Peptide Letters, 14(1) pp. 93–95.

Ribeiro, Lina; Silva, Nuno; Iley, Jim; Rautio, Jarkko; Järvinen, Tomi; Mota-Filipe, Hélder; Moreira, Rui and Mendes, Eduarda (2007). Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media. Archiv der Pharmazie, 340(1) pp. 32–40.

Jones, Raymond C.F.; Berthelot, Didier J.C. and Iley, James N. (2007). An alkylation route to carbo- and heteroaromatic amino acids. Arkivoc(11) pp. 73–84.

Jones, Raymond C.F.; Hollis, Stephen J. and Iley, James N. (2007). Intermolecular 1,3-dipolar cycloadditions of azomethine imines. Arkivoc(5) pp. 152–166.

Norberto, F.P.; Santos, S.P.; Iley, J.; Silva, D.B. and Corte Real, M. (2007). Kinetics and Mechanism of Hydrolysis of Benzimidazolylcarbamates. Journal of the Brazilian Chemical Society, 18(1) pp. 171–178.

Mulchande, Jalmira; Martins, Luísa; Moreira, Rui; Archer, Margarida; Oliveira, Tania F. and Iley, Jim (2007). The efficiency of C-4 substituents in activating the -lactam scaffold towards serine proteases and hydroxide ion. Organic and Biomolecular Chemistry, 5 pp. 2617–2626.

2006To Top

Chambel, Paula; Capela, Rita; Lopes, Francisca; Iley, Jim; Morais, Jose; Gouveia, Luıs; Gomes, Jose R. B.; Gomes, Paula and Moreira, Rui (2006). Reactivity of imidazolidin-4-one derivatives of primaquine: implications for prodrug design. Tetrahedron, 62(42) pp. 9883–9891.

Araujo, M. E. M.; Norberto, F.; Pamplona, T. and Iley, J. (2006). Mechanism of hydrolysis of substituted N-thiazolylcarbamate esters in OH- solutions. Journal of Chemical Research, 2006(10) pp. 664–667.

Valente, Claudia; Guedes, Rita C.; Moreira, Rui; Iley, Jim; Gut, Jiri and Rosenthal, Philip J. (2006). Dipeptide vinyl sultams: Synthesis via the Wittig–Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum. Bioorganic and Medicinal Chemistry Letters, 16(15) pp. 4115–4119.

Iley, Jim; Moreira, Rui; Martins, Luisa; Guedes, Rita C. and Soares, Claudio M. (2006). The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases. Bioorganic and Medicinal Chemistry Letters, 16(10) 2738 -2741.

Pivnevi, Levan; Dobbs, Adrian P.; Penny, Mark J.; Martinović, Sasa; Iley, James N. and Stephenson, Peter T. (2006). Monofluorinated di- and tetrahydropyrans via Prins-type cyclisations. Chemical Communications pp. 3134–3136.

Lory, Pedro M.J.; Jones, Raymond C.F.; Iley, James N.; Coles, Simon J. and Hursthouse, Michael B. (2006). Intramolecular 1,3-dipolar cycloadditions of dihydroimidazolium ylides: synthesis of pyrrolo[1,2,3-de]quinoxalines and imidazo[1,2-a]indoles. Organic and Biomolecular Chemistry, 4 pp. 3155–3165.

Da Pieve, C.; Bakhtyari, A.; Perkins, A. C.; Iley, J. and Missailidis, S. (2006). DNA aptamers as novel radiopharmaceuticals for imaging and targeted radiotherapy of epithelial tumours. In: European Association of Nuclear Medicine '06, 30 Sep - 04 Oct 2006, Athens, Greece.

2005To Top

Moreira, Rui; Santana, Ana Bela; Iley, Jim; Neres, Joao; Douglas, Kenneth T.; Horton, Peter N. and Hursthouse, Michael B. (2005). Design, Synthesis, and Enzymatic Evaluation of N1-Acyloxyalkyl- and N1-Oxazolidin-2,4-dion-5-yl-Substituted beta-lactams as Novel Inhibitors of Human Leukocyte Elastase. Journal of Medicinal Chemistry, 48(15) pp. 4861–4870.

Araújo, Maria Joao; Bom, Joana; Capela, Rita; Casimiro, Catarina; Chambel, Paula; Gomes, Paula; Iley, Jim; Lopes, Francisca; Morais, Jose; Moreira, Rui; de Oliveira, Eliandre; do Rosário, Virgilio and Vale, Nuno (2005). Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials. Journal of Medicinal Chemistry, 48 pp. 888–892.

Carvalho, Emilia; Francisco, Ana Paula; Iley, Jim and Rosa, Eduarda (2005). The mechanism of hydrolysis of aryl ether derivatives of 3-hydroxymethyltriazenes. European Journal of Organic Chemistry, 2005(10) pp. 2056–2063.

Ragazzon, P.; Iley, J. N. and Missailidis, S. (2005). Novel DNA-binding chemotherapeutic agents based on flavonoid scaffolds. In: NCRI Cancer Conference, 2-5 Oct 2005, Birmingham, U.K..

2004To Top

Lopes, Francisca; Capela, Rita; Gonçaves, Jose O.; Horton, Peter N.; Hursthouse, Michael B.; Iley, Jim; Casimiro, Catarina M.; Bom, Joana and Moreira, Rui (2004). Amidomethylation of amodiaquine: antimalarial N-Mannich base derivatives. Tetrahedron Letters, 45(41) 7663 -7666.

Gomes, Paula; Araújo, Maria J.; Rodrigues, Manuela; Vale, Nuno; Azevedo, Zelia; Iley, Jim; Chambel, Paula; Morais, Jose and Moreira, Rui (2004). Synthesis of imidazolidin-4-one and 1H-imidazo[2,1-a]isoindole-2,5(3H,9bH)-dione derivatives of primaquine: scope and limitations. Tetrahedron, 60(26) pp. 5551–5562.

Valente, Emilia; Gomes, J. Richard. B.; Moreira, Rui and Iley, Jim (2004). Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one. Journal of Organic Chemistry, 69 pp. 3359–3367.

Constantino, Luis and Iley, Jim (2004). Oxidation of tertiary benzamides by 5,10,15,20-tetraphenylporphyrinatoiron (III) chloride – tert-butylhydroperoxide. Organic and Biomolecular Chemistry, 2(13) pp. 1894–1900.

2003To Top

Ragazzon, P.; Iley, J. N. and Missailidis, S. (2003). Molecular encounters between active ingredients from herbal remedies and DNA. In: Fourth European Workshop in Drug Design (4EWDD), 25 May - 01 Jun 2003, Siena, Italy.

2002To Top

Mendes, Eduarda; Furtado, Tania; Neres, Joao; Iley, Jim; Jarvinen, Tomi; Rautio, Jarkko and Moreira, Rui (2002). Synthesis, stability and in vitro dermal evaluation of Aminocarbonyloxymethyl Esters as prodrugs of Carboxylic Acid Agents. Bioorganic and Medicinal Chemistry, 10(3) pp. 809–816.

Jones, Raymond C. F.; Iley, James N. and Lory, Pedro M. J. (2002). Synthesis of some new 2-heterosubstituted 4,5-dihydroimidazoles. Arkivoc(6) pp. 152–163.

2001To Top

Tolando, Roberto; Zanovella, Alberta; Ferrara, Roberta; Iley, Jim N. and Manno, Maurizzio (2001). Inactivation of rat liver cytochrome P450 (P450) by N,N-dimethylformamide and N,N-dimethylacetamide. Toxicology Letters, 124(1-3) pp. 101–111.

Jones, Raymond C. F.; Berthelot, Didier J.C. and Iley, James N. (2001). Synthesis by conjugate radical addition of new heterocyclic amino acids with nucleobase side chains. Tetrahedron, 57(30) pp. 6539–6555.

Jones, Raymond C. F.; Iley, James N.; Lory, Pedro M. J.; Coles, Simon C.; Light, Mark E. and Hursthouse, Michael B. (2001). Pyrrolo[1,2,3-de]quinoxalines: unexpected products from 1,3-dipolar cycloaddition of dihydroimidazolium ylides. Tetrahedron Letters, 42(23) pp. 3951–3954.

Clemente, A.; Domingos, A.; Grancho, A. P.; Iley, James; Moreira, R.; Neres, J.; Palma, N.; Santana, A. B. and Valente, E. (2001). Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors. Bioorganic and Medicinal Chemistry Letters, 11(8) pp. 1065–1068.

Iley, Jim; Tolando, Roberto and Constantino, Luis (2001). Chemical and microsomal oxidation of tertiary amides: regio-and stereoselective aspects. Journal of the Chemical Society: Perkin Transactions 2 pp. 1299–1305.

Iley, James; Lopes, Francisca and Moreira, Rui (2001). Kinetics and mechanism of N-amidomethylsulfonamides. Journal of the Chemical Society: Perkin Transactions 2(5) pp. 749–753.

Araújo, M. Eduarda M.; Campelo, Margarida; Iley, Jim and Norberto, Fatima (2001). Hydrolysis of aryl N-methyl-N-arenesulfonylcarbamates. Journal of the Chemical Society: Perkin Transactions 2 pp. 494–497.

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