Currently browsing: Items authored or edited by Ignacio A Romero

127 items in this list.
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2020To Top

Francisco, David M. F.; Marchetti, Luca; Rodríguez-Lorenzo, Sabela; Frias-Anaya, Eduardo; Figueiredo, Ricardo M.; Winter, Peter; Romero, Ignacio Andres; de Vries, Helga E.; Engelhardt, Britta; Bruggmann, Rémy and BtRAIN Network, (2020). Advancing brain barriers RNA sequencing: guidelines from experimental design to publication. Fluids and barriers of the CNS, 17(1), article no. 51.

2019To Top

Goodall, Emily F.; Leach, Vicki; Wang, Chunfang; Cooper-Knock, Johnathan; Heath, Paul R.; Baker, David; Drew, David R.; Saffrey, M. Jill; Simpson, Julie E.; Romero, Ignacio A. and Wharton, Stephen B. (2019). Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier. International Journal of Molecular Sciences, 20(12), article no. 3097.

Aparicio-Blanco, Juan; Romero, Ignacio A.; Male, David K.; Slowing, Karia; Garcia-Garcia, Luis and Torres-Suarez, Ana (2019). Cannabidiol Enhances the Passage of Lipid Nanocapsules across the Blood–Brain Barrier Both in Vitro and in Vivo. Molecular Pharmaceutics, 16(5) pp. 1999–2010.

Lopez-Ramirez, Miguel Alejandro; Pham, Angela; Girard, Romuald; Wyseure, Tine; Hale, Preston; Yamashita, Atsuki; Koskimäki, Janne; Polster, Sean; Saadat, Laleh; Romero, Ignacio A.; Esmon, Charles T.; Lagarrigue, Frederic; Awad, Issam A.; Mosnier, Laurent O. and Ginsberg, Mark H. (2019). Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood, 133(3) pp. 193–204.

2018To Top

Silva-Abreu, Marcelle; Calpena, Ana Cristina; Benito, Pol Andres; Romero, Ignacio A.; Roig-Carles, David; Gromnicova, Radka; Espina, Marta; Ferrer, Isidre; Garcia, Maria Luisa and Male, David (2018). PPARγ agonist-loaded PLGA -PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies. International Journal of Nanomedicine, 13 pp. 5577–5590.

Williams, Sarah K.; Fairless, Richard; Maier, Olaf; Liermann, Patricia C.; Pichi, Kira; Fischer, Roman; Eisel, Ulrich L. M.; Kontermann, Roland; Herrmann, Andreas; Weksler, Babette; Romero, Nacho; Couraud, Pierre-Olivier; Pfizenmaier, Klaus and Diem, Ricarda (2018). Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Scientific reports, 8 pp. 1–14.

Juan-Larrea, Naiara; Mather, Rebecca; Romero, Ignacio A.; Sibson, Nicola R. and Crea, Francesco (2018). The role of long non-coding RNAs in breast cancer dissemination to the brain. In: CRUK brain tumour conference, 1-3 May 2018, London.

Goodall, Emily F.; Wang, Chunfang; Simpson, Julie E.; Baker, David J.; Drew, David R.; Heath, Paul R.; Saffrey, M. Jill; Romero, Ignacio A. and Wharton, Stephen B. (2018). Age-associated changes in the blood brain barrier: Comparative studies in human and mouse. Neuropathology and Applied Neurobiology, 44(3) pp. 328–340.

2017To Top

Brilha, Sara; Ong, Catherine W M; Weksler, Babette; Romero, Nacho; Couraud, Pierre-Olivier and Friedland, Jon S (2017). Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis. Scientific Reports, 7, article no. 16031.

Greenwood, John; Hammarlund-Udenaes, Margareta; Jones, Hazel C; Stitt, Alan W; Vandenbrouke, Roosmarijn E; Romero, Ignacio A.; Campbell, Matthew; Fricker, Gert; Brodin, Birger; Manninga, Heiko; Gaillard, Pieter J; Schwaninger, Markus; Webster, Carl; Wicher, Krzysztof B and Khrestchatisky, Michel (2017). Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017. Fluids and barriers of the CNS, 14(1) p. 31.

Silva de Abreu, Marcelle; Calpena, Ana C.; Espina, Marta; Garcia, Maria Luisa; Romero, Ignacio A. and Male, David (2017). Toxicity and internalization of polymeric nanoparticles in brain endothelial cells. In: Fluids and Barriers of the CNS, BioMed Central, 14(Supp2) p. 19.

Couch, Yvonne; Akbar, Naveed; Roodselaar, Jay; Evans, Matthew C; Gardiner, Chris; Sargent, Ian; Romero, Ignacio A.; Bristow, Adrian; Buchan, Alastair M; Haughey, Norman and Anthony, Daniel C (2017). Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation. Scientific reports, 7(1) p. 9574.

Bader, Almke; Bintig, Willem; Begandt, Daniela; Klett, Anne; Siller, Ina G.; Gregor, Carola; Schaarschmidt, Frank; Weksler, Babette; Romero, Ignacio; Couraud, Pierre-Olivier; Hell, Stefan W. and Ngezahayo, Anaclet (2017). Adenosine receptors regulate gap junction coupling of the human cerebral microvascular endothelial cells hCMEC/D3 by Ca2+ influx through cyclic nucleotide-gated channels. The Journal of Physiology, 595(8) pp. 2497–2517.

Moreau, Nathan; Mauborgne, Annie; Couraud, Pierre-Olivier; Romero, Ignacio A; Weksler, Babette B; Villanueva, Luis; Pohl, Michel and Boucher, Yves (2017). Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? Molecular pain, 13 pp. 1–16.

Pucci, Perla; Venalainen, Erik; Mather, Rebecca; Xue, Hui; Rigas, Sushila; Romero, Ignacio A; Wang, Yuzho and Crea, Francesco (2017). Identification of a long non-coding RNA that mediates response to therapy in castration-resistant prostate cancer. In: 3rd International Cancer Symposium, 25-27 Sep 2017, Lyon, France.

2016To Top

Gromnicova, Radka; Kaya, Mehmet; Romero, Ignacio A.; Williams, Phil; Satchell, Simon; Sharrack, Basil and Male, David (2016). Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues. PLoS ONE, 11(8), article no. e0161610.

Lopez-Ramirez, Miguel Alejandro; Reijerkerk, Arie; de Vries, Helga E. and Romero, Ignacio Andres (2016). Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation. The FASEB Journal, 30(8) pp. 2662–2672.

Helms, Hans C; Abbott, N Joan; Burek, Malgorzata; Cecchelli, Romeo; Couraud, Pierre-Olivier; Deli, Maria A; Förster, Carola; Galla, Hans J; Romero, Ignacio A; Shusta, Eric V; Stebbins, Matthew J; Vandenhaute, Elodie; Weksler, Babette and Brodin, Birger (2016). In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. Journal of Cerebral Blood Flow & Metabolism, 36(5) pp. 862–890.

Moreau, Nathan; Mauborgne, Annie; Bourgoin, Sylvie; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette B.; Villanueva, Luis; Pohl, Michel and Boucher, Yves (2016). Early alterations of Hedgehog signaling pathway in vascular endothelial cells after peripheral nerve injury elicit blood-nerve barrier disruption, nerve inflammation, and neuropathic pain development. PAIN, 157(4) pp. 827–839.

Gromnicova, Radka; Yilmaz, Canan Ugur; Orhan, Nurcan; Kaya, Mehmet; Davies, Heather; Williams, Phil; Romero, Ignacio A.; Sharrack, Basil and Male, David (2016). Localisation and mobility of glucose-coated gold nanoparticles within the brain. Nanomedicine, 11(6) pp. 617–625.

2015To Top

Garwood, Claire J.; Ratcliffe, Laura E.; Morgan, Sarah V.; Simpson, Julie E.; Owens, Helen; Vazquez-Villaseñor, Irina; Heath, Paul R.; Romero, Ignacio A.; Ince, Paul G. and Wharton, Stephen B. (2015). Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Molecular Brain, 8(1), article no. 51.

Sun, P.; Esteban, G.; Inokuchi, T.; Marco-Contelles, J.; Weksler, B. B.; Romero, I. A.; Couraud, P. O.; Unzeta, M. and Solé, M. (2015). Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions, an in vitro experimental model of cerebral ischemia. British Journal of Pharmacology, 172(22) pp. 5390–5402.

Duperray, Alain; Barbe, Delphin; Raguenez, Gilda; Weksler, Babette B.; Romero, Ignacio A.; Couraud, Pierre-Olivier; Perron, Hervé and Marche, Patrice N. (2015). Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4. International Immunology, 27(11) pp. 545–553.

Krishnan, Subramanian; Chang, Alexander C.; Hodges, Jacqueline; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette; Nicholson, Bryon A.; Nolan, Lisa K. and Prasadarao, Nemani V. (2015). Serotype O18 avian pathogenic and neonatal meningitis Escherichia coli strains employ similar pathogenic strategies for the onset of meningitis. Virulence, 6(8) pp. 777–786.

Wijetunge, D. S. S.; Gongati, S.; DebRoy, C.; Kim, K. S.; Couraud, P. O.; Romero, I. A.; Weksler, B. and Kariyawasam, S. (2015). Characterizing the pathotype of neonatal meningitis causing Escherichia coli (NMEC). BMC Microbiology, 15, article no. 211.

Volle, Romain; Archimbaud, Christine; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette; Mirand, Audrey; Pereira, Bruno; Henquell, Cécile; Peigue-Lafeuille, Hélène and Bailly, Jean-Luc (2015). Differential permissivity of human cerebrovascular endothelial cells to enterovirus infection and specificities of enterovirus 71 in crossing an in vitro model of human blood brain barrier. Journal of General Virology, 96 pp. 1682–1695.

Wu, Dongsheng; Cerutti, Camilla; Lopez-Ramirez, Alejandro; Pryce, Gareth; King-Robson, Josh; Simpson, Julie E.; van der Pol, Susanne M. A.; Hirst, Mark C.; de Vries, Helga E.; Sharrack, Basil; Baker, David; Male, David K.; Michael, Gregory J. and Romero, Ignacio A (2015). Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. Journal of Cerebral Blood Flow & Metabolism, 35(3) pp. 412–23.

Al-Shehri, Abdulghani; Favretto, Marco E.; Ioannou, Panayiotis V.; Romero, Ignacio A.; Couraud, Pierre-Olivier; Weksler, Babette Barbash; Parker, Terry L. and Kallinteri, Paraskevi (2015). Permeability of PEGylated immunoarsonoliposomes through in vitro blood brain barrier: medulloblastoma co-culture models for brain tumor therapy. Pharmaceutical research, 32(3) pp. 1072–83.

Kamphuis, W. W.; Derada Troletti, C.; Reijerkerk, A.; Romero, I. A. and de Vries, H. E. (2015). The blood-brain barrier in multiple sclerosis: microRNAs as key regulators. CNS & Neurological Disorders Drug Targets, 14(2) pp. 157–67.

2014To Top

Dos Santos Pereira, Joao N.; Tadjerpisheh, Sina; Abu Abed, Manar; Saadatmand, Ali R.; Weksler, Babette; Romero, Ignacio A.; Couraud, Pierre-Olivier; Brockmöller, Jürgen and Tzvetkov, Mladen V. (2014). The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family. AAPS Journal, 16(6) pp. 1247–1258.

Marcos-Ramiro, Beatriz; Oliva Nacarino, Pedro; Serrano-Pertierra, Esther; Blanco-Gelaz, Miguel Ángel; Weksler, Babette B.; Romero, Ignacio A.; Couraud, Pierre O.; Tuñón, Alberto; López-Larrea, Carlos; Millán, Jaime and Cernuda-Morollón, Eva (2014). Microparticles in multiple sclerosis and clinically isolated syndrome: effect on endothelial barrier function. BMC Neuroscience, 15, article no. 110.

Bhupathiraju, N. V. S. Dinesh K.; Hu, Xiaoke; Zhou, Zehua; Fronczek, Frank R.; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette and Vicente, M. Graça H. (2014). Synthesis and in vitro evaluation of BBB permeability, tumor cell uptake, and cytotoxicity of a series of carboranylporphyrin conjugates. Journal of Medicinal Chemistry, 57(15) pp. 6718–28.

Lopez-Ramirez, Miguel Alejandro; Wu, Dongsheng; Pryce, Gareth; Simpson, Julie E.; Reijerkerk, Arie; King-Robson, Josh; Kay, Oliver; de Vries, Helga E.; Hirst, Mark C.; Sharrack, Basil; Baker, David; Male, David Kingsley; Michael, Gregory J. and Romero, Ignacio Andres (2014). MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB Journal, 28(6) pp. 2551–2565.

Omatsu, Tatsushi; Cepinskas, Gediminas; Clarson, Cheril; Patterson, Eric K.; Alharfi, Ibrahim M.; Summers, Kelly; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette and Fraser, Douglas D. (2014). CXCL1/CXCL8 (GROα/IL-8) in human diabetic ketoacidosis plasma facilitates leukocyte recruitment to cerebrovascular endothelium in vitro. American Journal of Physiology. Endocrinology and Metabolism, 306(9) E1077-E1084.

Naik, Pooja; Fofaria, Neel; Prasad, Shikha; Sajja, Ravi K.; Weksler, Babette; Couraud, Pierre-Olivier; Romero, Ignacio A. and Cucullo, Luca (2014). Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe? BMC Neuroscience, 15, article no. 51.

Raghnaill, Michelle Nic; Bramini, Mattia; Ye, Dong; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette; Aberg, Christoffer; Salvati, Anna; Lynch, Iseult and Dawson, Kenneth A. (2014). Paracrine signalling of inflammatory cytokines from an in vitro blood brain barrier model upon exposure to polymeric nanoparticles. Analyst, 139(5) pp. 923–930.

Qosa, Hisham; Abuasal, Bilal S.; Romero, Ignacio A.; Weksler, Babette; Couraud, Pierre-Oliver; Keller, Jeffrey N. and Kaddoumi, Amal (2014). Differences in amyloid-β clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling. Neuropharmacology, 79 pp. 668–678.

Noack, Andreas; Noack, Sandra; Hoffmann, Andrea; Maalouf, Katia; Buettner, Manuela; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette; Alms, Dana; Römermann, Kerstin; Naim, Hassan Y. and Löscher, Wolfgang (2014). Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C. PloS one, 9(2), article no. e88154.

2013To Top

Chaitanya, Ganta V.; Cromer, Walter E.; Parker, Courtney P.; Couraud, Pierre O.; Romero, Ignacio A; Weksler, Babette; Mathis, J. Michael; Minagar, Alireza and Alexander, J. Steven (2013). A recombinant inhibitory isoform of vascular endothelial growth factor164/165 aggravates ischemic brain damage in a mouse model of focal cerebral ischemia. American Journal of Pathology, 183(3) pp. 1010–1024.

Basivireddy, Jayasree; Somvanshi, Rishi K.; Romero, Ignacio A; Weksler, Babette B.; Couraud, Pierre-Olivier; Oger, Joel and Kumar, Ujendra (2013). Somatostatin preserved blood brain barrier against cytokine induced alterations: possible role in multiple sclerosis. Biochemical Pharmacology, 86(4) pp. 497–507.

Reuter, B.; Rodemer, C.; Grudzenski, S.; Couraud, P.-O.; Weksler, B.; Romero, Ignacio A; Meairs, S.; Bugert, P.; Hennerici, M. G and Fatar, M. (2013). Temporal profile of matrix metalloproteinases and their inhibitors in a human endothelial cell culture model of cerebral ischemia. Cerebrovascular Diseases, 35(6) pp. 514–520.

Dickens, David; Yusof, Siti R.; Abbott, N. Joan; Weksler, Babette; Romero, Ignacio A; Couraud, Pierre-Olivier; Alfirevic, Ana; Pirmohamed, Munir and Owen, Andrew (2013). A multi-system approach assessing the interaction of anticonvulsants with P-gp. PLoS ONE, 8(5), article no. e64854.

Duan, Hongxia; Xing, Shu; Luo, Yongting; Feng, Liqun; Gramaglia, Irene; Zhang, Ying; Lu, Di; Zeng, Qiqun; Fan, Kelong; Feng, Jing; Yang, Dongling; Qin, Zhihai; Couraud, Pierre-Olivier; Romero, Ignacio A; Weksler, Babette and Yan, Xiyun (2013). Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS. Scientific reports, 3, article no. 1687.

Reijerkerk, Arie; Lopez-Ramirez, M. Alejandro; van Het Hof, Bert; Drexhage, Joost A. R.; Kamphuis, Wouter W.; Kooij, Gijs; Vos, Joost B.; van der Pouw Kraan, Tineke C. T. M.; van Zonneveld, Anton J.; Horrevoets, Anton J.; Prat, Alexandre; Romero, Ignacio A and de Vries, Helga E. (2013). MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis. The Journal of Neuroscience, 33(16) pp. 6857–6863.

Bao Dang, Quoc; Lapergue, Bertrand; Tran-Dinh, Alexy; Diallo, Devy; Moreno, Juan-Antonio; Mazighi, Mikael; Romero, Ignacio A.; Weksler, Babette; Michel, Jean-Baptiste; Amarenco, Pierre and Meilhac, Olivier (2013). High-density lipoproteins limit neutrophil-induced damage to the blood–brain barrier in vitro. Journal of Cerebral Blood Flow & Metabolism, 33(4) pp. 575–582.

Griep, L. M.; Wolbers, F.; de Wagenaar, B.; ter Braak, P. M.; Weksler, B. B.; Romero, I. A; Couraud, P. O.; Vermes, I.; van der Meer, A. D. and van den Berg, A. (2013). BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function. Biomedical Microdevices, 15(1) pp. 145–150.

Daniels, Brian P.; Cruz-Orengo, Lillian; Pasieka, Tracy Jo; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette; Cooper, John A.; Doering, Tamara L. and Klein, Robyn S. (2013). Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier. Journal of Neuroscience Methods, 212(1) pp. 173–179.

Cristante, Enrico; McArthur, Simon; Mauro, Claudio; Maggioli, Elisa; Romero, Ignacio A.; Wylezinska-Arridge, Marzena; Couraud, Pierre O.; Lopez-Tremoleda, Jordi; Christian, Helen C.; Weksler, Babette B.; Malaspina, Andrea and Solito, Egle (2013). Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proceedings of the National Academy of Sciences of the United States of America, 110(3) pp. 832–841.

Weksler, Babette; Romero, Ignacio A. and Couraud, Pierre-Olivier (2013). The hCMEC/D3 cell line as a model of the human blood brain barrier. Fluids and barriers of the CNS, 10(1), article no. 16.

Navarro-Sobrino, Míriam; Hernández-Guillamon, Mar; Fernandez-Cadenas, Israel; Ribó, Marc; Romero, Ignacio A; Couraud, Pierre-Olivier; Weksler, Babette Barbash; Montaner, Joan and Rosell, Anna (2013). The angiogenic gene profile of circulating endothelial progenitor cells from ischemic stroke patients. Vascular Cell, 5(3) p. 3.

Wang, C.; Saffrey, M. J. and Romero, I. A. (2013). Age-related changes in blood-brain barrier integrity in C57BL/6J mice. In: British Society for Research on Ageing Annual Scientific Meeting, 2-4 Sep 2013, Institute of Food Research, University of East Anglia, Norwich, p. 36.

2012To Top

Pinzón-Daza, M. L.; Garzón, R.; Couraud, P. O.; Romero, I. A.; Weksler, B.; Ghigo, D.; Bosia, A. and Riganti, C. (2012). The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases the in vitro drug delivery across blood-brain barrier cells. British Journal of Pharmacology, 167(7) pp. 1431–1447.

Li, Tengfei; Bourgeois, Jean-Pierre; Celli, Susanna; Glacial, Fabienne; Le Sourd, Anne-Marie; Mecheri, Salah; Weksler, Babette; Romero, Ignacio; Couraud, Pierre-Olivier; Rougeon, François and Lafaye, Pierre (2012). Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging. FASEB Journal, 26(10) pp. 3969–3979.

Laakkonen, Johanna P.; Engler, Tatjana; Romero, Ignacio A; Weksler, Babette; Couraud, Pierre-Olivier; Kreppel, Florian and Kochanek, Stefan (2012). Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro. PLoS ONE, 7(9) e45977.

Roberts, Toni K; Eugenin, Eliseo A; Lopez, Lillie; Romero, Ignacio A; Weksler, Babette B; Couraud, Pierre-Olivier and Berman, Joan W (2012). CCL2 disrupts the adherens junction: implications for neuroinflammation. Laboratory investigation; a journal of technical methods and pathology, 92(8) pp. 1213–1233.

Kooijmans, Sander A. A.; Senyschyn, Danielle; Mezhiselvam, Muguntha M.; Morizzi, Julia; Charman, Susan A.; Weksler, Babette; Romero, Ignacio-Andres; Couraud, Pierre-Olivier and Nicolazzo, Joseph A. (2012). The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine. Molecular pharmaceutics, 9(4) pp. 883–93.

Dickens, David; Owen, Andrew; Alfirevic, Ana; Giannoudis, Athina; Davies, Andrea; Weksler, Babette; Romero, Ignacio A; Couraud, Pierre-Olivier and Pirmohamed, Munir (2012). Lamotrigine is a substrate for OCT1 in brain endothelial cells. Biochemical Pharmacology, 83(6) pp. 805–814.

Fletcher, Nicola F.; Wilson, Garrick K.; Murray, Jacinta; Hu, Ke; Lewis, Andrew; Reynolds, Gary M.; Stamataki, Zania; Meredith, Luke W.; Rowe, Ian A.; Luo, Guangxiang; Lopez-Ramirez, Miguel A.; Baumert, Thomas F.; Weksler, Babette; Couraud, Pierre-Olivier; Kim, Kwang Sik; Romero, Ignacio A.; Jopling, Catherine; Morgello, Susan; Balfe, Peter and McKeating, Jane A. (2012). Hepatitis C Virus infects the endothelial cells of the blood-brain barrier. Gastroenterology, 142(3) 634-643.e6.

Fouillet, A.; Mawson, J.; Suliman, O.; Sharrack, B.; Romero, I. A. and Woodroofe, M. N. (2012). CCL2 binding is CCR2 independent in primary adult human astrocytes. Brain research, 1437 pp. 115–26.

Watson, Christopher P.; Dogruel, Murat; Mihoreanu, Larisa; Begley, David J.; Weksler, Babette B.; Couraud, Pierre O.; Romero, Ignacio A. and Thomas, Sarah A. (2012). The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: Evidence for involvement of breast cancer resistance protein. Brain research, 1436 pp. 111–121.

Bintig, Willem; Begandt, Daniela; Schlingmann, Barbara; Gerhard, Linda; Pangalos, Maria; Dreyer, Lutz; Hohnjec, Natalija; Couraud, Pierre-Olivier; Romero, Ignacio A; Weksler, Babette B. and Ngezahayo, Anaclet (2012). Purine receptors and Ca2+ signalling in the human blood-brain barrier endothelial cell line hCMEC/D3. Purinergic Signalling, 8(1) pp. 71–80.

Lopez-Ramirez, Alejandro; Fischer, Roman; Torres-Badillo, Claudia C.; Davies, Heather A.; Logan, Karen; Pfizenmaier, Klaus; Male, David K.; Sharrack, Basil and Romero, Ignacio A. (2012). Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells. Journal of Immunology, 189(6) pp. 3130–3139.

Freese, Christian; Uboldi, Chiara; Gibson, Matthew I.; Unger, Ronald E.; Weksler, Babette B.; Romero, Ignacio A.; Couraud, Pierre-Olivier and Kirkpatrick, C. J. (2012). Uptake and cytotoxicity of citrate-coated gold nanospheres: Comparative studies on human endothelial and epithelial cells. Particle and Fibre Toxicology, 9, article no. 23.

Schrade, Anja; Sade, Hadassah; Couraud, Pierre-Olivier; Romero, Ignacio A; Weksler, Babette B and Niewoehner, Jens (2012). Expression and localization of claudins-3 and -12 in transformed human brain endothelium. Fluids and barriers of the CNS, 9 p. 6.

2011To Top

Hatherell, Kathryn; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette and Pilkington, Geoffrey J. (2011). Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models. Journal of neuroscience methods, 199(2) pp. 223–229.

Shen, Weiyong; Li, Shiying; Chung, Sook Hyun; Zhu, Ling; Stayt, Jason; Su, Tao; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette and Gillies, Mark C. (2011). Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium. European Journal of Cell Biology, 90(4) pp. 323–332.

Markoutsa, Eleni; Pampalakis, Georgios; Niarakis, Anna; Romero, Ignacio A.; Weksler, Babette; Couraud, Pierre-Olivier and Antimisiaris, Sophia G. (2011). Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line. European Journal of Pharmaceutics and Biopharmaceutics, 77(2) pp. 265–274.

Georgieva, Julia V.; Kalicharan, Dharamdajal; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette; Hoekstra, Dick and Zuhorn, Inge S (2011). Surface characteristics of nanoparticles determine their intracellular fate in and processing by human blood–brain barrier endothelial cells in vitro. Molecular Therapy, 19(2) pp. 318–325.

Faria, Ana; Pestana, Diogo; Teixeira, Diana; Couraud, Pierre-Olivier; Romero, Ignacio A; Weksler, Babette; de Freitas, Victor; Mateus, Nuno and Calhau, Conceição (2011). Insights into the putative catechin and epicatechin transport across blood-brain barrier. Food & Function(2) pp. 39–44.

Mills, Jeffrey H.; Alabanza, Leah; Weksler, Babette B.; Couraud, Pierre-Olivier; Romero, Ignacio A. and Bynoe, Margaret S. (2011). Human brain endothelial cells are responsive to adenosine receptor activation. Purinergic Signalling, 7(2) pp. 265–273.

Chaitanya, Ganta V.; Cromer, Walter E.; Wells, Shannon R.; Jennings, Merilyn H.; Couraud, P. Oliver; Romero, Ignacio A; Weksler, Babette; Erdreich-Epstein, Anat; Mathis, James Michael; Minagar, Alireza and Alexander, J. Steven (2011). Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro. Journal of Neuroinflammation, 8(162)

2010To Top

Bhattacharya, Raktima; Xu, Yan; Rahman, Md. Ashequr; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette B.; Weidanz, Jon A. and Bickel, Ulrich (2010). A novel vascular targeting strategy for brain-derived endothelial cells using a TCR mimic antibody. Journal of Cellular Physiology, 225(3) pp. 664–672.

Carl, Stephen M.; Lindley, David J.; Couraud, Pierre O.; Weksler, Babette B.; Romero, Ignacio; Mowery, Stephanie A. and Knipp, Gregory T. (2010). ABC and SLC transporter expression and POT substrate characterization across the human CMEC/D3 blood-brain barrier cell line. Molecular Pharmaceutics, 7(4) pp. 1057–1068.

Najbauer, Joseph; Haarmann, Axel; Deiß, Annika; Prochaska, Jürgen; Foerch, Christian; Weksler, Babette; Romero, Ignacio; Couraud, Pierre-Olivier; Stoll, Guido; Rieckmann, Peter and Buttmann, Mathias (2010). Evaluation of soluble junctional adhesion molecule-a as a biomarker of human brain endothelial barrier breakdown. PLoS ONE, 5(10) e13568.

van Rooy, Inge; Cakir-Tascioglu, Serpil; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette; Storm, Gert; Hennink, Wim E.; Schiffelers, Raymond M. and Mastrobattista, Enrico (2010). Identification of peptide ligands for targeting to the blood-brain barrier. Pharmaceutical Research, 27(4) pp. 673–682.

2009To Top

Ramirez, Servio H.; Potula, Raghava; Fan, Shongshan; Eidem, Tess; Papugani, Anil; Reichenbach, Nancy; Dykstra, Holly; Weksler, Babette B.; Romero, Ignacio A.; Couraud, Pierre O. and Persidsky, Yuri (2009). Methamphetamine disrupts blood–brain barrier function by induction of oxidative stress in brain endothelial cells. Journal of Cerebral Blood Flow and Metabolism, 29(12) pp. 1933–1945.

Joice, Shannon L.; Mydeen, Firdau; Couraud, Pierre-Olivier; Weksler, Babette B.; Romero, Ignacio A.; Fraser, Paul A. and Easton, Alexander S. (2009). Modulation of blood-brain barrier permeability by neutrophils: in vitro and in vivo studies. Brain Research, 1298 pp. 13–23.

Fischer, Silvia; Nishio, Miwako; Peters, Saskia C.; Tschernatsch, Marlene; Walberer, Maureen; Weidemann, Susanne; Heidenreich, Regina; Couraud, Pierre O.; Weksler, Babette B.; Romero, Ignacio A.; Gerriets, Tibo and Preissner, Klaus T. (2009). Signaling mechanism of extracellular RNA in endothelial cells. FASEB Journal, 23(7) pp. 2100–2109.

Coureuil, Mathieu; Mikaty, Guillain; Miller, Florence; Lécuyer, Hervé; Bernard, Christine; Bourdoulous, Sandrine; Duménil, Guillaume; Mège, René-Marc; Weksler, Babette B.; Romero, Ignacio A.; Couraud, Pierre Olivier and Nassif, Xavier (2009). Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium. Science, 325(5936) pp. 83–87.

Hurst, Louise A.; Bunning, Rowena A.D.; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette B.; Sharrack, Basil and Woodroofe, M. Nicola (2009). Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment. Journal of Neuroimmunology, 210(1-2) pp. 108–112.

Vukic, Vanja; Callaghan, Debbie; Walker, David; Lue, Lih-Fen; Liu, Qing Yan; Couraud, Pierre-Oliver; Romero, Ignacio A.; Weksler, Babette; Stanimirovic, Danica B. and Zhang, Wandong (2009). Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway. Neurobiology of Disease, 34(1) pp. 95–106.

Zastre, Jason A.; Chan, Gary N. Y.; Ronaldson, Patrick T.; Ramaswamy, Manisha; Couraud, Pierre O.; Romero, Ignacio A.; Weksler, Babette; Bendayan, Moise and Bendayan, Reina (2009). Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line. Journal of Neuroscience Research, 87(4) pp. 1023–1036.

Dauchy, Sandrine; Miller, Florence; Couraud, Pierre-Olivier; Weaver, Richard, J.; Weksler, Babette; Romero, Ignacio A.; Scherrmann, Jean-Michel; De Waziers, Isabelle and Decleves, Xavier (2009). Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells. Biochemical Pharmacology, 77(5) pp. 897–909.

Sade, Hadassah; Holloway, Karen; Romero, Ignacio A. and Male, David (2009). Transcriptional control of occludin expression in vascular endothelia: regulation by Sp3 and YY1. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1789(3) pp. 175–184.

Bahbouhi, Bouchaib; Berthelot, Laureline; Pettré, Ségolène; Michel, Laure; Wiertlewski, Sandrine; Weksler, Babette; Romero, Ignacio A.; Miller, Florence; Couraud, Pierre-Olivier; Brouard, Sophie; Laplaud, David-Axel and Soulillou, Jean-Paul (2009). Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line. Journal of Leukocyte Biology, 86(5) pp. 1049–1063.

Mkrtchyan, H.; Scheler, S.; Klein, I.; Fahr, A.; Couraud, P. O.; Romero, I. A.; Weksler, B. and Liehr, T. (2009). Molecular cytogenetic characterization of the human cerebral microvessel endothelial cell line hCMEC/D3. Cytogenetic and Genome Research, 126 pp. 313–317.

2008To Top

Poller, Birk; Gutmann, Heike; Krahenbuhl, Stephan; Weksler, Babette; Romero, Ignacio A.; Couraud, Pierre-Olivier; Tuffin, Gerald; Drewe, Jürgen and Huwyler, Jörg (2008). The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies. Journal of Neurochemistry, 107(5) pp. 1358–1368.

Afonso, Philippe V.; Ozden, Simona; Cumont, Marie-Christine; Seilhean, Danielle; Cartier, Luis; Rezaie, Payam; Mason, Sarah; Lambert, Sophie; Huerre, Michel; Gessain, Antoine; Couraud, Pierre-Olivier; Pique, Claudine; Ceccaldi, Pierre-Emmanuel and Romero, Ignacio A. (2008). Alteration of blood–brain barrier integrity by retroviral infection. PLoS Pathogens, 4(11), article no. e1000205.

Wilhelm, Imola; Nagyoszi, Péter; Farkas, Attila E.; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette; Fazakas, Csilla; Dung, Ngo Thi Khue; Bottka, Sándor; Bauer, Hannelore; Bauer, Hans-Christian and Krizbai, István A. (2008). Hyperosmotic stress induces axl activation and cleavage in cerebral endothelial cells. Journal of Neurochemistry, 107(1) pp. 116–126.

András, I. E.; Rha, G.; Huang, W.; Eum, S.; Couraud, P. O.; Romero, I. A.; Henning, B. and Toborek, M. (2008). Simvastatin Protects against Amyloid β and HIV-1 Tat-Induced Promoter Activities of Inflammatory Genes in Brain Endothelial Cells. Molecular Pharmacology, 73(5) pp. 1424–1433.

Förster, C.; Burek, M.; Romero, I. A.; Weksler, B.; Couraud, P. O. and Drenckhahn, D. (2008). Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. Journal of Physiology, 586(7) pp. 1937–1949.

Cucullo, Luca; Couraud, Pierre-Olivier; Weksler, Babette; Romero, Ignacio-Andres; Hossain, Mohammed M; Rapp, Edward and Janigro, Damir (2008). Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies. Journal of Cerebral Blood Flow and Metabolism, 28(2) pp. 312–328.

Lim, Joseph C.; Kania, Katarzyna D.; Wijesuriya, Hasini; Chawla, Sangeeta; Sethi, Jaswinder K.; Pulaski, Lukasz; Romero, Ignacio A.; Couraud, Pierre O.; Weksler, Babette B.; Hladky, Stephen B. and Barrand, Margery A. (2008). Activation of β-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. Journal of Neurochemistry, 106(4) pp. 1855–1865.

2007To Top

Schreibelt, G.; Kooij, G.; Reijerkerk, A.; van Doorn, R.; Gringhuis, S.I.; van der Poll, S.M.A.; Weksler, B.B.; Romero, Ignacio A; Couraud, P.O.; Piontek, J.; Blasig, I.E.; Dijkstra, Christine D.; Ronken, E. and de Vries, H.E. (2007). Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling. FASEB Journal, 21(13) pp. 3666–3676.

Wilhelm, Imola; Farkas, Attila E.; Nagyoszi, Peter; Varo, Gyorgy; Balint, Zoltan; Vegh, Gergely A.; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette and Krizbai, Istvan A. (2007). Regulation of cerebral endothelial cell morphology by extracellular calcium. Physics in medicine and biology, 52(20) pp. 6261–6274.

Afonso, P.V.; Ozden, S.; Prevost, M.C.; Schmitt, C.; Seilhan, D.; Weksler, B.B.; Couraud, P.O.; Gessain, A.; Romero, I.A. and Ceccaldi, P.E. (2007). Human Blood Brain Barrier Disruption by Retroviral Infected Lymphocytes: Role of Myosin Light Chain Kinase in Endothelial Tight-Junction Disorganization. Journal of Immunology, 179(4) pp. 2576–2583.

2006To Top

Couraud, P.O.; Romero, I.A. and Weksler, B.B. (2006). Human Blood Brain Barrier Model. INSERM; Cornell University; Couraud, P.O.; Romero, I.A.; Weksler, B.B., WO/2006/056879.

2005To Top

Weksler, B.B.; Subileau, E.A.; Perriere, N.; Charneau, P.; Holloway, K.; Leveque, M.; Tricoire-Leignel, H.; Nicotra, A.; Bourdolos, S.; Tourowski, P.; Male, D.K.; Roux, F.; Greenwood, J.; Romero, I.A. and Couraud, P.O. (2005). Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB Journal, 19(13) pp. 1872–1874.

2004To Top

Bailey, T. A.; Kanuga, N.; Romero, I. A.; Greenwood, J.; Luthert, P. J. and Cheetham, M. E. (2004). Oxidative stress affects the junctional integrity of retinal pigment epithelial cells. Investigative Ophthalmology and Visual Science, 45(2) pp. 675–684.

2003To Top

Didier, Nathalie; Romero, Ignacio A.; Creminon, Christophe; Wijkhuisen, Anne; Grassi, Jacques and Mabondzo, Aloise (2003). Secretion of interleukin-1β by astrocytes mediates endothelin-1 and tumour necrosis factor-α effects on human brain microvascular endothelial cell permeability. Journal of Neurochemistry, 86(1) pp. 246–254.

Romero, I.A.; Radewicz, K.; Jubin, E.; Michel, C.C.; Greenwood, J.; Couraud, P.O. and Adamson, P. (2003). Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells. Neuroscience Letters, 344(2) pp. 112–116.

Flynn, Geraldine; Maru, Seema; Loughlin, Jane; Romero, Ignacio A. and Male, David (2003). Regulation of chemokine receptor expression in human microglia and astrocytes. Journal of Neuroimmunology, 136(1-2) pp. 84–93.

2002To Top

Romero, I.A.; Amos, C.L.; Greenwood, J. and Adamson, P. (2002). Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated. Molecular Brain Research, 105(1-2) pp. 47–59.

Romero, Ignacio A.; Hazan, Uriel; Cancello, Raffaella; Valente, Susana; Perrin, Virginie; Mariot, Virginie; Dumonceaux, Julie; Cindy C., Gerhardt; Strosberg, A. Donny; Courard, Pierre-Olivier and Pietri-Rouxel, France (2002). Human adipose cells express CD4, CXCR4, and CCR5 receptors: a new target cell type for the immunodeficiency virus-1? FASEB Journal, 16(8) pp. 1254–1256.

2001To Top

Gerhardt, C. C.; Romero, Ignacio A; Cancello, R.; Camoin, L. and Strosberg, A. D. (2001). Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Molecular and cellular endocrinology, 175(1 - 2) pp. 81–92.

Amos, Claire; Romero, Ignacio A.; Schulze, Charlotte; Rousell, Jonathan; Pearson, Jeremy D.; Greenwood, John and Adamson, Peter (2001). Cross-linking of brain endothelial intercellular adhesion molecule (ICAM)-1 induces association of ICAM-1 with detergent-insoluble cytoskeletal fraction. Arteriosclerosis, Thrombosis, and Vascular Biology, 21 pp. 810–816.


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