Currently browsing: Items authored or edited by Christopher Heath https://orcid.org/0000-0003-3485-7128

Aitta-aho, Teemu; Phillips, Benjamin U.; Pappa, Elpiniki; Hay, Y. Audrey; Harnischfeger, Fiona; Heath, Christopher J.; Saksida, Lisa M.; Bussey, Timothy J. and Apergis-Schoute, John (2017). Accumbal cholinergic interneurons differentially influence motivation related to satiety signaling. eNeuro, 4(2), article no. e0328-16.

• Download Version of Record (PDF / 2MB)

Contu, Laura; Nizari, Shereen; Heath, Christopher J. and Hawkes, Cheryl A. (2019). Pre- and postnatal high fat feeding differentially affects the structure and integrity of the neurovascular unit of 16-month old male and female mice. Frontiers in Neuroscience, 13, article no. 1045.

• Download Version of Record (PDF / 12MB)
• Download Supplementary Material (Image (JPEG) / 413kB)
• Download Supplementary Material (Image (JPEG) / 181kB)
• Download Supplementary Material (Image (JPEG) / 285kB)
• Download Supplementary Material (PDF / 7kB)
• Download Supplementary Material (PDF / 52kB)

Heath, Christopher; O'Callaghan, Claire; Mason, Sarah L; Phillips, Benjamin U; Saksida, Lisa M; Robbins, Trevor W; Barker, Roger A; Bussey, Timothy J and Sahakian, Barbara J (2019). A touchscreen motivation assessment evaluated in Huntington’s disease patients and R6/1 model mice. Frontiers in Neurology, 10, article no. 858.

• Download Version of Record (PDF / 804kB)

Hailwood, Jonathan M.; Heath, Christopher J.; Phillips, Benjamin U.; Robbins, Trevor W.; Saksida, Lisa M. and Bussey, Timothy J. (2019). Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation. Neuropsychopharmacology, 44 pp. 1068–1075.

• Download Accepted Manuscript (PDF / 944kB)

Hailwood, Jonathan M.; Heath, Christopher J.; Robbins, Trevor W.; Saksida, Lisa M. and Bussey, Timothy J. (2018). Validation and optimisation of a touchscreen progressive ratio test of motivation in male rats. Psychopharmacology, 235(9) pp. 2739–2753.

• Download Version of Record (PDF / 1MB)

Heath, Christopher J.; Phillips, Benjamin U.; Bussey, Timothy J. and Saksida, Lisa M. (2016). Measuring Motivation and Reward-Related Decision Making in the Rodent Operant Touchscreen System. In: Gerfen, Charles R.; Holmes, Andrew; Sibley, David; Skolnick, Phil and Wray, Susan eds. Current Protocols in Neuroscience, Volume 74. Chichester: John Wiley & Sons, 8.34.1-8.34.20.

Heath, Christopher J.; Bussey, Timothy J. and Saksida, Lisa M. (2015). Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs. Psychopharmacology, 232(21) pp. 4043–4057.

• Download Version of Record (PDF / 1MB)

Hvoslef-Eide, Martha; Oomen, C. A.; Fisher, B. M.; Heath, C. J.; Robbins, T. W.; Saksida, L. M. and Bussey, T. J. (2015). Facilitation of spatial working memory performance following intra-prefrontal cortical administration of the adrenergic alpha1 agonist phenylephrine. Psychopharmacology, 232(21) pp. 4005–4016.

• Download Version of Record (PDF / 1MB)

Hvoslef-Eide, M.; Mar, A. C.; Nilsson, S. R. O.; Alsiö, J.; Heath, C. J.; Saksida, L. M.; Robbins, T. W. and Bussey, T. J. (2015). The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia. Psychopharmacology

Horner, Alexa E.; Heath, Christopher J.; Hvoslef-Eide, Martha; Kent, Brianne A.; Kim, Chi Hun; Nilsson, Simon R. O.; Alsiö, Johan; Oomen, Charlotte A.; Holmes, Andrew; Saksida, Lisa M. and Bussey, Timothy J. (2013). The touchscreen operant platform for testing learning and memory in rats and mice. Nature Protocols, 8(10) pp. 1961–84.

Horst, Nicole K.; Heath, Christopher J.; Neugebauer, Nichole M.; Kimchi, Eyal Y.; Laubach, Mark and Picciotto, Marina R. (2012). Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion. Behavioural Brain Research, 231(1) pp. 170–180.

Heath, Christopher J.; Horst, Nicole K. and Picciotto, Marina R. (2010). Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence. Physiology & behavior, 101(5) pp. 764–769.

Heath, Christopher J.; King, Sarah L.; Gotti, Cecilia; Marks, Michael J. and Picciotto, Marina R. (2010). Cortico-Thalamic Connectivity is Vulnerable to Nicotine Exposure During Early Postnatal Development through α4/β2/α5 Nicotinic Acetylcholine Receptors. Neuropsychopharmacology, 35(12) pp. 2324–2338.

Heath, Christopher J. and Picciotto, Marina R. (2009). Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. Neuropharmacology, 56(Sup 1) pp. 254–262.

Jung, Yonwoo; Hsieh, Lawrence S.; Lee, Angela M.; Zhou, Zhifeng; Coman, Daniel; Heath, Christopher J.; Hyder, Fahmeed; Mineur, Yann S; Yuan, Qiaoping; Goldman, David; Bordey, Angelique and Picciotto, Marina R (2016). An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nature Neuroscience, 19(7) pp. 905–914.

• Download Accepted Manuscript (PDF / 76MB)

Jacobsen, Leslie K.; Picciotto, Marina R.; Heath, Christopher J.; Mencl, W. Einar and Gelernter, Joel (2009). Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents. Biological Psychiatry, 65(8) pp. 671–679.

Jacobsen, Leslie K.; Picciotto, Marina R.; Heath, Christopher; Frost, Stephen J.; Tsou, Kristen A.; Dwan, Rita A.; Jackowski, Marcel P.; Constable, Robert T. and Mencl, W. Einar (2007). Prenatal and Adolescent Exposure to Tobacco Smoke Modulates the Development of White Matter Microstructure. The Journal of Neuroscience, 27(49) pp. 13491–13498.

Kim, Eosu; White, Matthew A.; Phillips, Benjamin U.; Lopez-Cruz, Laura; Kim, Hyunjeong; Heath, Christopher J.; Lee, Jong Eun; Saksida, Lisa M.; Sreedharan, Jemeen and Bussey, Timothy J. (2020). Coexistence of perseveration and apathy in the TDP-43^Q331K knock-in mouse model of ALS–FTD. Translational Psychiatry, 10(1), article no. 377.

• Download Version of Record (PDF / 1MB)

Kent, Brianne A.; Heath, Christopher J.; Kim, Chi Hun; Ahrens, Rosemary; Fraser, Paul E.; St George-Hyslop, Peter; Bussey, Timothy J. and Saksida, Lisa M. (2018). Longitudinal evaluation of Tau-P301L transgenic mice reveals no cognitive impairments at 17 months of age. Brain and Behavior, 8(1), article no. e00896.

• Download Version of Record (PDF / 1MB)
• Download Supplementary Material (PDF / 790kB)

Kim, Eun Woo; Phillips, Benjamin U.; Heath, Christopher J.; Cho, So Yeon; Kim, Hyunjeong; Sreedharan, Jemeen; Song, Ho-Taek; Lee, Jong Eun; Bussey, Timothy J.; Kim, Chul Hoon; Kim, Eosu and Saksida, Lisa M. (2017). Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens. Molecular Brain, 10, article no. 31.

• Download Version of Record (PDF / 1MB)

Kim, Chi Hun; Romberg, Carola; Hvoslef-Eide, Martha; Oomen, Charlotte A.; Mar, Adam C.; Heath, Christopher J.; Berthiaume, Andrée-Anne; Bussey, Timothy J. and Saksida, Lisa M. (2015). Trial-unique, delayed nonmatching-to-location (TUNL) touchscreen testing for mice: sensitivity to dorsal hippocampal dysfunction. Psychopharmacology, 232(21) pp. 3935–3945.

• Download Version of Record (PDF / 1MB)

Kim, Chi Hun; Heath, Christopher J.; Kent, Brianne A.; Bussey, Timothy J. and Saksida, Lisa M. (2015). The role of the dorsal hippocampus in two versions of the touchscreen automated paired associates learning (PAL) task for mice. Psychopharmacology, 232(21) pp. 3899–3910.

• Download Version of Record (PDF / 3MB)

Lopez-Cruz, Laura and Heath, Christopher J. (2022). Motivation – Behavioral Approaches and Translational Potential. In: Della Salla, Sergio ed. Encyclopedia of Behavioral Neuroscience, 2nd edition. Elsevier, pp. 60–69.

Lopez-Cruz, Laura; Bussey, Timothy J.; Saksida, Lisa M. and Heath, Christopher (2021). Using touchscreen-delivered cognitive assessments to address the principles of the 3Rs in behavioural sciences. Lab Animal, 50 pp. 174–184.

• Request a copy from the authorAccepted Manuscript (PDF)
  This file is not available for public download until 16 December 2021

Lim, Jisoo; Kim, Eosu; Noh, Hyun Jong; Kang, Shinwon; Phillips, Benjamin U.; Kim, Dong Goo; Bussey, Timothy J.; Saksida, Lisa M.; Heath, Christopher J. and Kim, Chul Hoon (2019). Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses. Molecular Brain, 12, article no. 37.

• Download Version of Record (PDF / 1MB)

Nilsson, Simon R.O.; Heath, Christopher J.; Takillah, Samir; Didienne, Steve; Fejgin, Kim; Nielsen, Vibeke; Nielsen, Jacob; Saksida, Lisa M.; Mariani, Jean; Faure, Philippe; Didriksen, Michael; Robbins, Trevor W.; Bussey, Timothy J. and Mar, Adam C. (2018). Continuous performance test impairment in a 22q11.2 microdeletion mouse model: improvement by amphetamine. Translational Psychiatry, 8, article no. 247.

• Download Version of Record (PDF / 1MB)

Nilsson, Simon R. O.; Celada, Pau; Fejgin, Kim; Thelin, Jonas; Nielsen, Jacob; Santana, Noemí; Heath, Christopher J.; Larsen, Peter H.; Nielsen, Vibeke; Kent, Brianne A.; Saksida, Lisa M.; Stensbøl, Tine B.; Robbins, Trevor W.; Bastlund, Jesper F.; Bussey, Timothy J.; Artigas, Francesc and Didriksen, Michael (2016). A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment. Psychopharmacology

• Download Version of Record (PDF / 654kB)

Oomen, Charlotte A.; Hvoslef-Eide, Martha; Heath, Christopher J.; Mar, Adam C.; Horner, Alexa E.; Bussey, Timothy J. and Saksida, Lisa M. (2013). The touchscreen operant platform for testing working memory and pattern separation in rats and mice. Nature Protocols, 8(10) pp. 2006–2021.

Phillips, Benjamin U.; Dewan, Sigma; Nilsson, Simon R. O.; Robbins, Trevor W.; Heath, Christopher J.; Saksida, Lisa M.; Bussey, Timothy J. and Alsiö, Johan (2018). Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice. Psychopharmacology, 235(7) pp. 2101–2111.

• Download Version of Record (PDF / 1MB)

Phillips, Benjamin U.; Lopez-Cruz, Laura; Hailwood, Jonathan; Heath, Christopher J.; Saksida, Lisa M. and Bussey, Timothy J. (2018). Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures. Current Opinion in Behavioral Sciences, 22 pp. 21–27.

• Download Accepted Manuscript (PDF / 217kB)

Phillips, Benjamin U.; Heath, Christopher J.; Ossowska, Zofia; Bussey, Timothy J. and Saksida, Lisa M. (2017). Optimisation of cognitive performance in rodent operant (touchscreen) testing: Evaluation and effects of reinforcer strength. Learning and Behavior, 45(3) pp. 252–262.

• Download Version of Record (PDF / 1MB)

Romberg, Carola; McTighe, Stephanie M.; Heath, Christopher J.; Whitcomb, Daniel J.; Cho, Kwangwook; Bussey, Timothy J. and Saksida, Lisa M. (2012). False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine. Brain : a journal of neurology, 135(7) pp. 2103–2114.

• Download Version of Record (PDF / 574kB)

Steiner, Rebecca C.; Heath, Christopher J. and Picciotto, Marina R. (2007). Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII. Journal of Neurochemistry, 103(2) pp. 666–78.

• Download Version of Record (PDF / 597kB)