<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Fibronectin, Collagen, Fibrin - Components of Extracellular Matrix for Nerve Regeneration"^^ . "There are key differences in the extent to which the peripheral (PNS) and central (CNS) nervous\r\nsystems recover function following damage. In each case there is a balance between factors that\r\ninhibit and promote neuronal regeneration. In the CNS this balance is skewed toward inhibition\r\nwhile in the PNS it is skewed towards promotion of neuronal growth. Following damage the CNS\r\nenvironment is generally hostile to neuronal growth. However, axonal regeneration does occur under\r\ncertain conditions. In this review, various strategies for promotion of neuronal growth are explored\r\nincluding the use of tissue engineered grafts incorporating extracellular matrix proteins, synthetic\r\nmaterials, electrically active materials, coupled with biomolecular and cellular – based strategies.\r\nDevelopment of biosynthetic conduits carrying extracellular matrix molecules and cells (Schwann\r\ncells, olfactory ensheathing glia or stem cells) expressing neurotrophic growth factors represents a\r\nnovel and promising strategy for spinal cord and peripheral nerve repair. Native matrix scaffolds\r\n(e.g. collagen, fibrin, fibronectin) have been produced with appropriate biomimetic 3D mesoscale\r\nstructures for improving nervous system repair. The structure, composition, biomechanical\r\nproperties and effectiveness of such implants in supporting experimental PNS and CNS repair are\r\nreviewed and discussed in this chapter."^^ . "2007" . "3" . . "Biomaterials and Tissue Engineering Group"^^ . . . "Topics in Tissue Engineering"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . . . "A"^^ . "Alovskaya"^^ . "A Alovskaya"^^ . . "V"^^ . "King"^^ . "V King"^^ . . "N."^^ . "Ashammakhi"^^ . "N. Ashammakhi"^^ . . "R. L."^^ . "Reis"^^ . "R. L. Reis"^^ . . "R"^^ . "Brown"^^ . "R Brown"^^ . . "E."^^ . "Chiellini"^^ . "E. Chiellini"^^ . . "T"^^ . "Alekseeva"^^ . "T Alekseeva"^^ . . "JB"^^ . "Phillips"^^ . "JB Phillips"^^ . . . . . "HTML Summary of #9064 \n\nFibronectin, Collagen, Fibrin - Components of Extracellular Matrix for Nerve Regeneration\n\n" . "text/html" . .