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The nature and dynamics of bacterial genomes

Ochman, Howard and Davalos, Liliana M. (2006). The nature and dynamics of bacterial genomes. Science, 311(5768) pp. 1730–1733.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1126/science.1119966
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Abstract

Though generally small and gene rich, bacterial genomes are constantly subjected to both mutational and population-level processes that operate to increase amounts of functionless DNA. As a result, the coding potential of bacterial genomes can be substantially lower than originally predicted. Whereas only a single pseudogene was included in the original annotation of the bacterium Escherichia coli, we estimate that this genome harbors hundreds of inactivated and otherwise functionless genes. Such regions will never yield a detectable phenotype, but their identification is vital to efforts to elucidate the biological role of all the proteins within the cell.

Item Type: Journal Article
ISSN: 1095-9203
Academic Unit/Department: Science > Environment, Earth and Ecosystems
Interdisciplinary Research Centre: Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Item ID: 9536
Depositing User: Users 2315 not found.
Date Deposited: 28 Sep 2007
Last Modified: 02 Dec 2010 20:04
URI: http://oro.open.ac.uk/id/eprint/9536
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