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Cell responses to biomimetic protein scaffolds used in tissue repair and engineering

Brown, Robert A. and Phillips, James B. (2007). Cell responses to biomimetic protein scaffolds used in tissue repair and engineering. International Review of Cytology, 262 pp. 75–150.

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Basic science research in tissue engineering and regenerative medicine aims to investigate and understand the deposition, growth, and remodeling of tissues by drawing together approaches from a range of disciplines. This review discusses approaches that use biomimetic proteins and cellular therapies, both in the development of clinical products and of model platforms for scientific investigation. Current clinical approaches to repairing skin, bone, nerve, heart valves, blood vessels, ligaments, and tendons are described and their limitations identified. Opportunities and key questions for achieving clinical goals are discussed through commonly used examples of biomimetic scaffolds: collagen, fibrin, fibronectin, and silk. The key questions addressed by three-dimensional culture models, biomimetic materials, surface chemistry, topography, and their interaction with cells in terms of durotaxis, mechano-regulation, and complex spatial cueing are reviewed to give context to future strategies for biomimetic technology.

Item Type: Article
ISSN: 0074-7696
Keywords: Tissue engineering; biomimetic proteins; regenerative medicine; collagen; fibronectin; fibrin; silk; 3D modeling
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 9063
Depositing User: James Phillips
Date Deposited: 25 Sep 2007
Last Modified: 04 Oct 2016 10:05
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