Brown, Robert A. and Phillips, James B.
|DOI (Digital Object Identifier) Link:||http://doi.org/10.1016/S0074-7696(07)62002-6|
|Google Scholar:||Look up in Google Scholar|
Basic science research in tissue engineering and regenerative medicine aims to investigate and understand the deposition, growth, and remodeling of tissues by drawing together approaches from a range of disciplines. This review discusses approaches that use biomimetic proteins and cellular therapies, both in the development of clinical products and of model platforms for scientific investigation. Current clinical approaches to repairing skin, bone, nerve, heart valves, blood vessels, ligaments, and tendons are described and their limitations identified. Opportunities and key questions for achieving clinical goals are discussed through commonly used examples of biomimetic scaffolds: collagen, fibrin, fibronectin, and silk. The key questions addressed by three-dimensional culture models, biomimetic materials, surface chemistry, topography, and their interaction with cells in terms of durotaxis, mechano-regulation, and complex spatial cueing are reviewed to give context to future strategies for biomimetic technology.
|Item Type:||Journal Article|
|Keywords:||Tissue engineering; biomimetic proteins; regenerative medicine; collagen; fibronectin; fibrin; silk; 3D modeling|
|Academic Unit/Department:||Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
|Interdisciplinary Research Centre:||Biomedical Research Network (BRN)|
|Depositing User:||James Phillips|
|Date Deposited:||25 Sep 2007|
|Last Modified:||02 Aug 2016 13:09|
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