Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment

Fossey, John S.; Anslyn, Eric V.; Brittain, William D. G.; Bull, Steven D.; Chapin, Brette M.; Le Duff, Cécile S.; James, Tony D.; Lees, Glenn; Lim, Stephanie; Lloyd, Jennifer A. C.; Manville, Charles V.; Payne, Daniel T. and Roper, Kimberley A. (2017). Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment. Journal of Chemical Education, 94(1) pp. 79–84.

DOI: https://doi.org/10.1021/acs.jchemed.6b00355

Abstract

An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by 1H NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance for supporting the experiment.

Viewing alternatives

Metrics

Item Actions

Export

You can export this page using these formats Digital Object Identifier - DOI

About

• Item ORO ID
• 86863
• Item Type
• Journal Item
• ISSN
• 0021-9584
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © 2016 The American Chemical Society
• Depositing User
• ORO Import