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Hyde, Caroline Anna Clara and Ballmer-Hofer, Kurt
(2012).
DOI: https://doi.org/10.4414/smf.2012.01387
Abstract
Translated summary: This publication largely summarises our results obtained with the VEGFR-2 ECD-targeting DARPins in endothelial cell systems. At the same time, this article also provides an overview of the current state-of-the-art in terms of anti-angiogenic treatment and provides insight into the possible benefits of highly receptor-specific reagents that make use of a novel mechanism of allosteric inhibition. Lastly, this article presents initial data obtained from anti-VEGFR-2 D4-7-targeted inhibition in cancer cells directly and speculates about the application of these compounds in pre-clinical tumour therapy.
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About
- Item ORO ID
- 86222
- Item Type
- Journal Item
- ISSN
- 1424-3784
- Keywords
- VEGF; VEGF receptor; allosteric inhibition; endothelial cells; tumour therapy
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Research Group
- Cancer Research Group
- Depositing User
- Caroline Hyde