Die extrazelluläre Inhibition des VEGF-Rezeptors-2 durch Antikörper-ähnliche Peptidmoleküle: Implikationen für die Tumortherapie

Hyde, Caroline Anna Clara and Ballmer-Hofer, Kurt (2012). Die extrazelluläre Inhibition des VEGF-Rezeptors-2 durch Antikörper-ähnliche Peptidmoleküle: Implikationen für die Tumortherapie. Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, 12(50)

DOI: https://doi.org/10.4414/smf.2012.01387

Abstract

Translated summary: This publication largely summarises our results obtained with the VEGFR-2 ECD-targeting DARPins in endothelial cell systems. At the same time, this article also provides an overview of the current state-of-the-art in terms of anti-angiogenic treatment and provides insight into the possible benefits of highly receptor-specific reagents that make use of a novel mechanism of allosteric inhibition. Lastly, this article presents initial data obtained from anti-VEGFR-2 D4-7-targeted inhibition in cancer cells directly and speculates about the application of these compounds in pre-clinical tumour therapy.

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About

• Item ORO ID
• 86222
• Item Type
• Journal Item
• ISSN
• 1424-3784
• Keywords
• VEGF; VEGF receptor; allosteric inhibition; endothelial cells; tumour therapy
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Research Group
• Cancer Research Group
• Depositing User
• Caroline Hyde