Computational and Experimental Investigation of Microfluidic Chamber Designs for DNA Biosensors

Psoma, Sotiria D.; Sobianin, Ihor and Tourlidakis, Antonios (2022). Computational and Experimental Investigation of Microfluidic Chamber Designs for DNA Biosensors. Engineering Proceedings, 16(1), article no. 16.

DOI: https://doi.org/10.3390/IECB2022-12252

Abstract

A critical characteristic for continuous monitoring using DNA biosensors is the design of the microfluidics system used for sample manipulation, effective and rapid reaction and an ultra-low detection limit of the analyte. The selection of the appropriate geometrical design and control of microfluidic parameters are highly important for the optimum performance. In the present study, a number of different shapes of microchambers are designed and computationally assessed using a Multiphysics software. Flow parameters such as pressure drop, and shear rates are compared. Three-dimensional printing was used to construct the designs and an experimental investigation is underway for the validation of the computational results.

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