Computational and Experimental Investigation of Microfluidic Chamber Designs for DNA Biosensors

Psoma, Sotiria D.; Sobianin, Ihor and Tourlidakis, Antonios (2022). Computational and Experimental Investigation of Microfluidic Chamber Designs for DNA Biosensors. Engineering Proceedings, 16(1) pp. 1–14.

DOI: https://doi.org/10.3390/IECB2022-12252

URL: https://www.mdpi.com/2673-4591/16/1/16/htm

Abstract

A critical characteristic for continuous monitoring using DNA biosensors is the design of the microfluidics system used for sample manipulation, effective and rapid reaction and an ultra-low detection limit of the analyte. The selection of the appropriate geometrical design and control of microfluidic parameters are highly important for the optimum performance. In the present study, a number of different shapes of microchambers are designed and computationally assessed using a Multiphysics software. Flow parameters such as pressure drop, and shear rates are compared. Three-dimensional printing was used to construct the designs and an experimental investigation is underway for the validation of the computational results.

Viewing alternatives

Download history

Metrics

Public Attention

Altmetrics from Altmetric

Number of Citations

Citations from Dimensions

Item Actions

Export

About

Recommendations