Mileusnic, R.; Lancashire, C.; Clark, J. and Rose, S.
(2007). Protection against Ab induces memory loss by tripeptide D-Arg-L-Glu-D-Arg.
In: Iqbal, I.; Wingblat, B. and Avila, J. eds.
Alzheimer's Disease: New Advances.
Medimond International Proceedings.
Bologna, Italy: Medimond, pp. 435–438.
The diastomeric (D/L) form of acetylated tripeptide RER protects against A-beta induced memory loss for a passive avoidance task in young chicks and enhances retention for a weak version of the task when injected peripherally up to 12 hr prior to training. The tripeptide readilly crosses the blood-brain barrier, binds to membrane receptor sites in the brain and is whithout adverse effets on general behaviour. RER-related peptides may forma basis for a therapetic agent in the early stages of AD
||Alzheimer’s disease (AD) is a major and increasingly prevalent disease in an ageing society, affecting some 12 million people world-wide. Although there are a small number of licensed drugs which are of some utility in alleviating the symptoms of memory loss, it is widely recognised that these are at best palliative. A new approach focussing on different targets is needed if the effects of the disease are to be alleviated and its progression either slowed or prevented. As faulty processing of APP is a key step in the biochemical cascade leading both to plaque formation and the behavioural manifestations of AD, strategies to restore APP’s cell signalling function provide one such new approach for development of a novel therapeutic strategy. Focussing on APP and endeavouring to find ways of restoring its function is based on our observations of the behavioural effect of APP-related tripeptide Arg-Glu-Arg (RER) which not only protects against the amnestic effects of downregulating or functionally blocking APP, but also against the amnestic effect of amyloid beta (A)
||Alzheimer's disease, memory, enhancment, RER
||Science > Life, Health and Chemical Sciences
||27 Jul 2007
||02 Dec 2010 20:00
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