A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration

Saeed, Aram; Francini, Nora; White, Lisa; Dixon, James; Gould, Toby; Rashidi, Hassan; Al Ghanami, Racha Cheikh; Hruschka, Veronika; Redl, Heinz; Saunders, Brian R.; Alexander, Cameron and Shakesheff, Kevin M. (2015). A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration. Advanced Materials, 27(4) pp. 662–668.

DOI: https://doi.org/10.1002/adma.201403626

Abstract

A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postculture by the simple process of lowering the temperature and applying an external magnetic field. The colloidal gel can be reconfigured with thermal and magnetic stimuli to allow patterning of cells in discrete zones and to control movement of cells within the porous matrix during culture.

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About

• Item ORO ID
• 81088
• Item Type
• Journal Item
• ISSN
• 0935-9648
• Academic Unit or School
• Other Departments > Research, Enterprise and Scholarship
  Other Departments
• Copyright Holders
• © 2015 The Authors
• Depositing User
• Christopher Biggs