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Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold

Alcaro, Stefano; Artese, Anna; Iley, James N.; Maccari, Rosanna; Missailidis, Sotiris; Ortuso, Francesco; Ottana, Rosaria; Ragazzon, Patricia and Vigorita, Maria Gabriella (2007). Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold. Bioorganic and Medicinal Chemistry Letters, 17(9) pp. 2509–2514.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/j.bmcl.2007.02.022
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Abstract

A series of fluorenone-carboxamide compounds was analyzed with regard to DNA binding properties by UV spectroscopy
and competition dialysis methods. The morpholino derivative 10 provided interesting results in terms of affinity and specificity toward the DNA G-tetraplex structures. Interactions against this target were evaluated by a comparative molecular modeling study in agreement with the experimental data, proposing a model for the rational design of new agents with potent and selective DNA tetraplex binding properties.

Item Type: Journal Article
ISSN: 0960-894X
Keywords: DNA tetraplex; drug binding; molecular modeling
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 7446
Depositing User: James Iley
Date Deposited: 18 Apr 2007
Last Modified: 10 Mar 2014 10:31
URI: http://oro.open.ac.uk/id/eprint/7446
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