Abdoul-Carime, Hassan; Limao-Vieira, Paulo; Gohlke, Sascha; Petrushko, Irina; Mason, Nigel J. and Illenberger, Eugen
(2004).
| DOI (Digital Object Identifier) Link: | http://dx.doi.org/10.1016/j.cplett.2004.06.081 |
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| Google Scholar: | Look up in Google Scholar |
Abstract
Substitution of thymidine by 5-bromouridine within DNA sensitizes the nucleic acid to radiation. We show here the ability of low-energy (<12 eV) electrons, abundantly produced along the ionization tracks, to effectively decompose the radiosensitizer via two main fragmentation channels to produce the bromine anion and the 5-bromouracil-yl anion, with a cross-section of 2 x 10(-14) and 9 x 10(-16) cm(2), respectively. The formation of these negative fragments is accompanied by their corresponding reactive radicals, i.e., uracil-yl radical bound to the sugar moiety and 2-deoxyribose-yl radical, which are both considered as precursors for DNA strand breaks. (C) 2004 Elsevier B.V. All rights reserved.
| Item Type: | Journal Article |
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| ISSN: | 1873-4448 |
| Extra Information: | Some of the symbols may not have transferred correctly into this bibliographic record and/or abstract. |
| Keywords: | aqueous-solutions; liquid water; 5-halouracils; attachment; thymine; radiolysis; damage; DNA; dehalogenation; affinities |
| Academic Unit/Department: | Science > Physical Sciences |
| Interdisciplinary Research Centre: | Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR) eSTEeM |
| Item ID: | 6843 |
| Depositing User: | Astrid Peterkin |
| Date Deposited: | 13 Feb 2007 |
| Last Modified: | 05 Mar 2014 10:29 |
| URI: | http://oro.open.ac.uk/id/eprint/6843 |
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