Abdoul-Carime, Hassan; Limao-Vieira, Paulo; Gohlke, Sascha; Petrushko, Irina; Mason, Nigel J. and Illenberger, Eugen
(2004).
DOI (Digital Object Identifier) Link: | https://doi.org/10.1016/j.cplett.2004.06.081 |
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Abstract
Substitution of thymidine by 5-bromouridine within DNA sensitizes the nucleic acid to radiation. We show here the ability of low-energy (<12 eV) electrons, abundantly produced along the ionization tracks, to effectively decompose the radiosensitizer via two main fragmentation channels to produce the bromine anion and the 5-bromouracil-yl anion, with a cross-section of 2 x 10(-14) and 9 x 10(-16) cm(2), respectively. The formation of these negative fragments is accompanied by their corresponding reactive radicals, i.e., uracil-yl radical bound to the sugar moiety and 2-deoxyribose-yl radical, which are both considered as precursors for DNA strand breaks. (C) 2004 Elsevier B.V. All rights reserved.
Item Type: | Journal Item |
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ISSN: | 1873-4448 |
Extra Information: | Some of the symbols may not have transferred correctly into this bibliographic record and/or abstract. |
Keywords: | aqueous-solutions; liquid water; 5-halouracils; attachment; thymine; radiolysis; damage; DNA; dehalogenation; affinities |
Academic Unit/School: | Faculty of Science, Technology, Engineering and Mathematics (STEM) > Physical Sciences Faculty of Science, Technology, Engineering and Mathematics (STEM) |
Research Group: | Physics |
Item ID: | 6843 |
Depositing User: | Astrid Peterkin |
Date Deposited: | 13 Feb 2007 |
Last Modified: | 12 Feb 2018 10:17 |
URI: | http://oro.open.ac.uk/id/eprint/6843 |
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