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The role of perivascular innervation and neurally mediated vasoreactivity in the pathophysiology of Alzheimer's disease

Nizari, Shereen; Romero, Ignacio A. and Hawkes, Cheryl A. (2017). The role of perivascular innervation and neurally mediated vasoreactivity in the pathophysiology of Alzheimer's disease. Clinical Science, 131(12) pp. 1207–1214.

DOI (Digital Object Identifier) Link: https://doi.org/10.1042/cs20160769
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Abstract

Neuronal death is a hallmark of Alzheimer's disease (AD) and considerable work has been done to understand how the loss of interconnectivity between neurons contributes to the associated dementia. Often overlooked however, is how the loss of neuronal innervation of blood vessels, termed perivascular innervation, may also contribute to the pathogenesis of AD. There is now considerable evidence supporting a crucial role for the neurovascular unit (NVU) in mediating the clearance of the β-amyloid (Aβ) peptide, one of the main pathological constituents of AD, from the brain. Moreover, efficient removal appears to be dependent on the communication of cells within the NVU to maintain adequate vascular tone and pulsatility. This review summarizes the composition of the NVU, including the sources of perivascular innervation and how the NVU mediates Aβ clearance from the brain. It also explores evidence supporting the hypothesis that loss of neurally mediated vasoreactivity contributes to Aβ pathology in the AD brain.

Item Type: Journal Item
Copyright Holders: 2017 The Author(s)
ISSN: 1470-8736
Keywords: Alzheimers disease; blood vessel; innervation; vasoreactivity
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 67945
SWORD Depositor: Jisc Publications-Router
Depositing User: Jisc Publications-Router
Date Deposited: 04 Nov 2019 09:15
Last Modified: 18 Nov 2019 10:46
URI: http://oro.open.ac.uk/id/eprint/67945
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