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Terasaki spiral ramps and intracellular diffusion

Huber, Greg and Wilkinson, Michael (2019). Terasaki spiral ramps and intracellular diffusion. Physical Biology, 16(6), article no. 065002.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1088/1478-3975/ab4080
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Abstract

The sheet-like endoplasmic reticulum (ER) of eukaryotic cells has been found to be riddled with spiral dislocations, known as 'Terasaki ramps', in the vicinity of which the doubled bilayer membranes which make up ER sheets can be approximately modeled by helicoids. Here we analyze diffusion on a surface with locally helicoidal topological dislocations, and use the results to argue that the Terasaki ramps facilitate a highly efficient transport of water-soluble molecules within the lumen of the endoplasmic reticulum.

Item Type: Journal Item
Copyright Holders: 2019 IOP Publishing Ltd
ISSN: 1478-3975
Keywords: Terasaki ramps; anomalous diffusion; cell biology; cytoplasmic diffusion; diffusion; endoplasmic reticulum; organelles
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 66696
SWORD Depositor: Jisc Publications-Router
Depositing User: Jisc Publications-Router
Date Deposited: 17 Sep 2019 08:16
Last Modified: 15 Nov 2019 09:11
URI: http://oro.open.ac.uk/id/eprint/66696
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