The Open UniversitySkip to content
 

Treatment-emergent neuroendocrine prostate cancer: molecularly driven clinical guidelines

Clermont, Pier-Luc; Ci, Xinpei; Pandha, Hardev; Wang, Yuzhuo and Crea, Francesco (2019). Treatment-emergent neuroendocrine prostate cancer: molecularly driven clinical guidelines. International Journal of Endocrine Oncology, 6(2), article no. IJE20.

Full text available as:
[img]
Preview
PDF (Version of Record) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (917kB) | Preview
DOI (Digital Object Identifier) Link: https://doi.org/10.2217/ije-2019-0008
Google Scholar: Look up in Google Scholar

Abstract

An increasingly recognized mechanism of prostate cancer resistance is the transdifferentiation from adenocarcinoma to treatment-emergent neuroendocrine prostate cancer (t-NEPC), an extremely aggressive malignancy. The incidence of t-NEPC has been increasing in recent years, in part due to novel treatments that target the androgen receptor pathway. While clinicians historically had very few options for t-NEPC detection and treatment, recent research has uncovered key diagnostic tools and therapeutic targets that can be translated into improved patient care. In this article, we will outline the clinical features of t-NEPC and its molecular pathogenesis. Importantly, we will also discuss recently uncovered molecularly based strategies aimed at improving the diagnosis and treatment of t-NEPC. Finally, we will propose a unified algorithm that integrates clinical and molecular information for the clinical management of t-NEPC.

Item Type: Journal Item
Copyright Holders: 2019 Pier-Luc Clermont
ISSN: 2045-0877
Keywords: androgen; cancer, clinical; diagnosis; epigenetics; guidelines; imaging; neuroendocrine; prostate; therapy
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 66679
SWORD Depositor: Jisc Publications-Router
Depositing User: Jisc Publications-Router
Date Deposited: 16 Sep 2019 11:57
Last Modified: 11 Nov 2019 20:44
URI: http://oro.open.ac.uk/id/eprint/66679
Share this page:

Metrics

Altmetrics from Altmetric

Citations from Dimensions

Download history for this item

These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.

Actions (login may be required)

Policies | Disclaimer

© The Open University   contact the OU