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Development of a 3D coculture system to study adipocyte and lymph node cell interactions

Daya, S.; Loughlin, J. and MacQueen, H. (2006). Development of a 3D coculture system to study adipocyte and lymph node cell interactions. In: Tissue and cell engineering systems meeting 2006, 3-4 July 2006, Sheffield, UK.

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Abstract

We have developed a long term 3-dimensional coculture system with adipocytes and lymph node
cells for the purpose of investigating interactions between these cells in vitro. Present experimental work with the culture system is aimed at introducing lymph node cells, in proportions similar to those found in intact lymph nodes, among differentiated adipocytes and observing interactions and the establishment of a spatial relationship between them. Co-cultures will be used to investigate the lymph node adipocyte interactions following immune stimulation (lipopolysaccharide treatment) measuring production of inflammatory mediators (cytokines) and lipolytic activity.

Item Type: Conference Item
Keywords: 3D culture; adipocyte; lymph node; cytokine
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 6335
Depositing User: Hilary MacQueen
Date Deposited: 31 Jan 2007
Last Modified: 07 Mar 2014 23:50
URI: http://oro.open.ac.uk/id/eprint/6335
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