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Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier

Goodall, Emily F.; Leach, Vicki; Wang, Chunfang; Cooper-Knock, Johnathan; Heath, Paul R.; Baker, David; Drew, David R.; Saffrey, M. Jill; Simpson, Julie E.; Romero, Ignacio A. and Wharton, Stephen B. (2019). Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier. International Journal of Molecular Sciences, 20(12), article no. 3097.

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DOI (Digital Object Identifier) Link: https://doi.org/10.3390/ijms20123097
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Abstract

Functional and structural age-associated changes in the blood-brain barrier (BBB) may affect the neurovascular unit and contribute to the onset and progression of age-associated neurodegenerative pathologies, including Alzheimer’s disease. The current study interrogated the RNA profile of the BBB in an ageing human autopsy brain cohort and an ageing mouse model using combined laser capture microdissection and expression profiling. Only 12 overlapping genes were altered in the same direction in the BBB of both ageing human and mouse cohorts. These included genes with roles in regulating vascular tone, tight junction protein expression and cell adhesion, all processes prone to dysregulation with advancing age. Integrated mRNA and miRNA network and pathway enrichment analysis of the datasets identified 15 overlapping miRNAs that showed altered expression. In addition to targeting genes related to DNA binding and/or autophagy, many of the miRNAs identified play a role in age-relevant processes, including BBB dysfunction and regulating the neuroinflammatory response. Future studies have the potential to develop targeted therapeutic approaches against these candidates to prevent vascular dysfunction in the ageing brain.

Item Type: Journal Item
Copyright Holders: 2019 The Authors
ISSN: 1422-0067
Keywords: ageing; blood brain barrier; gene expression; miRNA
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 62195
SWORD Depositor: Jisc Publications-Router
Depositing User: Jisc Publications-Router
Date Deposited: 28 Jun 2019 08:05
Last Modified: 28 Jun 2019 14:09
URI: http://oro.open.ac.uk/id/eprint/62195
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