Kilburn, John P.; Lau, Jesper and Jones, Raymond C.F.
|DOI (Digital Object Identifier) Link:||http://doi.org/10.1016/S0040-4039(01)00222-2|
|Google Scholar:||Look up in Google Scholar|
A new approach to the synthesis of 1,3,4-oxadiazoles on solid support is described. Resin bound 1-acyl thiosemicarbazides were treated with a variety of dehydrating agents at different temperatures, which revealed that thiosemicarbazides were effectively cyclised by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC . HCl); mild acidic cleavage from the solid support released the substituted 1,3,4-oxadiazoles in excellent purity.
|Item Type:||Journal Article|
|Keywords:||derivatives; phase; chemistry|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences
|Depositing User:||Astrid Peterkin|
|Date Deposited:||25 Jan 2007|
|Last Modified:||14 Jan 2016 16:21|
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