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1,3,4-oxadiazole formation; a novel solid support strategy

Kilburn, John P.; Lau, Jesper and Jones, Raymond C.F. (2001). 1,3,4-oxadiazole formation; a novel solid support strategy. Tetrahedron Letters, 42(13) pp. 2583–2586.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/S0040-4039(01)00222-2
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Abstract

A new approach to the synthesis of 1,3,4-oxadiazoles on solid support is described. Resin bound 1-acyl thiosemicarbazides were treated with a variety of dehydrating agents at different temperatures, which revealed that thiosemicarbazides were effectively cyclised by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC . HCl); mild acidic cleavage from the solid support released the substituted 1,3,4-oxadiazoles in excellent purity.

Item Type: Journal Article
ISSN: 0040-4039
Keywords: derivatives; phase; chemistry
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Item ID: 6199
Depositing User: Astrid Peterkin
Date Deposited: 25 Jan 2007
Last Modified: 02 Dec 2010 19:55
URI: http://oro.open.ac.uk/id/eprint/6199
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