Kilburn, John P.; Lau, Jesper and Jones, Raymond C.F.
|DOI (Digital Object Identifier) Link:||http://doi.org/10.1016/S0040-4020(02)00033-9|
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A new facile solid-phase synthesis of N,N',N"-substituted guanidines from an immobilised amine component is described. The resin-bound amine was reacted with di-(2-pyridyl)thionocarbonate to generate the isothiocyanate which was treated with aryl/alkyl amines to yield the corresponding resin-bound thiourea. Desulfurisation of the thiourea was readily achieved by treatment with triphenylphosphine dichloride, and further reaction with aryl/alkyl amines followed by acidic cleavage with trifluoroacetic acid yielded N,N',N"-substituted guanidines of excellent purity and in good yield. (C) 2002 Elsevier Science Ltd. All rights reserved.
|Item Type:||Journal Article|
|Keywords:||N,N ',N ''-substituted guanidines; parallel synthesis; thioureas|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences
|Depositing User:||Astrid Peterkin|
|Date Deposited:||15 Feb 2007|
|Last Modified:||14 Jan 2016 16:21|
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