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Substituted 2-amino-1,3,4-thiadiazines: a novel solid-phase approach

Kilburn, John Paul; Lau, Jesper and Jones, Raymond C. F. (2002). Substituted 2-amino-1,3,4-thiadiazines: a novel solid-phase approach. Tetrahedron Letters, 43(18) pp. 3309–3311.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/S0040-4039(02)00525-7
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Abstract

A novel and facile strategy for synthesis of substituted 2-amino-1,3,4-thiadiazines on solid support is described. Resin bound isothiocyanate prepared from an immobilised primary amine and di-(2-pyridyl)thionocarbonate was reacted with hydrazine hydrate to form the intermediate thiosemicarbazide. Further reaction with a range of alpha-bromoketones followed by mild acidic cleavage from the solid support released the substituted 2-amino-1,3,4-thiadiazines in respectable yields and excellent purity. (C) 2002 Elsevier Science Ltd. All rights reserved.

Item Type: Journal Article
ISSN: 0040-4039
Keywords: Chemistry
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Item ID: 6169
Depositing User: Astrid Peterkin
Date Deposited: 15 Feb 2007
Last Modified: 02 Dec 2010 19:55
URI: http://oro.open.ac.uk/id/eprint/6169
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