Kilburn, John Paul; Lau, Jesper and Jones, Raymond C. F.
|DOI (Digital Object Identifier) Link:||http://dx.doi.org/10.1016/S0040-4039(02)00525-7|
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A novel and facile strategy for synthesis of substituted 2-amino-1,3,4-thiadiazines on solid support is described. Resin bound isothiocyanate prepared from an immobilised primary amine and di-(2-pyridyl)thionocarbonate was reacted with hydrazine hydrate to form the intermediate thiosemicarbazide. Further reaction with a range of alpha-bromoketones followed by mild acidic cleavage from the solid support released the substituted 2-amino-1,3,4-thiadiazines in respectable yields and excellent purity. (C) 2002 Elsevier Science Ltd. All rights reserved.
|Item Type:||Journal Article|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences
|Depositing User:||Astrid Peterkin|
|Date Deposited:||15 Feb 2007|
|Last Modified:||14 Jan 2016 16:21|
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