The Open UniversitySkip to content
 

Genetic components of human pain sensitivity: a protocol for a genome-wide association study of experimental pain in healthy volunteers

Schmid, Annina B.; Adhikari, Kaustubh; Ramirez-Aristeguieta, Luis Miguel; Chacón-Duque, Juan-Camilo; Poletti, Giovanni; Gallo, Carla; Rothhammer, Francisco; Bedoya, Gabriel; Ruiz-Linares, Andres and Bennett, David L (2019). Genetic components of human pain sensitivity: a protocol for a genome-wide association study of experimental pain in healthy volunteers. BMJ Open, 9(4) e025530.

Full text available as:
[img]
Preview
PDF (Version of Record) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (1MB) | Preview
DOI (Digital Object Identifier) Link: https://doi.org/10.1136/bmjopen-2018-025530
Google Scholar: Look up in Google Scholar

Abstract

Introduction Pain constitutes a major component of the global burden of diseases. Recent studies suggest a strong genetic contribution to pain susceptibility and severity. Whereas most of the available evidence relies on candidate gene association or linkage studies, research on the genetic basis of pain sensitivity using genome-wide association studies (GWAS) is still in its infancy. This protocol describes a proposed GWAS on genetic contributions to baseline pain sensitivity and nociceptive sensitisation in a sample of unrelated healthy individuals of mixed Latin American ancestry.
Methods and analysis A GWAS on genetic contributions to pain sensitivity in the naïve state and following nociceptive sensitisation will be conducted in unrelated healthy individuals of mixed ancestry. Mechanical and thermal pain sensitivity will be evaluated with a battery of quantitative sensory tests evaluating pain thresholds. In addition, variation in mechanical and thermal sensitisation following topical application of mustard oil to the skin will be evaluated.
Ethics and dissemination This study received ethical approval from the University College London research ethics committee (3352/001) and from the bioethics committee of the Odontology Faculty at the University of Antioquia (CONCEPTO 01–2013). Findings will be disseminated to commissioners, clinicians and service users via papers and presentations at international conferences.

Item Type: Journal Item
Copyright Holders: 2019 The Authors
ISSN: 2044-6055
Project Funding Details:
Funded Project NameProject IDFunding Body
Newton Fund Institutional Links Grant216398412British Research Council
Excellence Initiative of Aix-Marseille University— A*MIDEXNot SetNot Set
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Mathematics and Statistics
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 60653
Depositing User: Kaustubh Adhikari
Date Deposited: 25 Apr 2019 14:11
Last Modified: 30 Apr 2019 01:24
URI: http://oro.open.ac.uk/id/eprint/60653
Share this page:

Metrics

Altmetrics from Altmetric

Citations from Dimensions

Download history for this item

These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.

Actions (login may be required)

Policies | Disclaimer

© The Open University   contact the OU