Effects of ultrasound on Transforming Growth Factor-beta genes in bone cells

Harle, J.; Mayia, F.; Olsen, I. and Salih, V. (2005). Effects of ultrasound on Transforming Growth Factor-beta genes in bone cells. European Cells and Materials, 10 pp. 70–77.

URL: http://www.ecmjournal.org/journal/papers/vol010/vo...

Abstract

Therapeutic ultrasound (US) is a widely used form of biophysical stimulation that is increasingly applied to promote fracture healing. Transforming growth factor-beta (TGF-beta), which is encoded by three related but different genes, is known to play a major part in bone growth and repair. However, the effects of US on the expression of the TGF-beta genes and the physical acoustic mechanisms involved in initiating changes in gene expression in vitro, are not yet known. The present study demonstrates that US had a differential effect on these TGF-beta isoforms in a human osteoblast cell line, with the highest dose eliciting the most pronounced up-regulation of both TGF-beta1 and TGF-beta3 at 1 hour after treatment and thereafter declining. In contrast, US had no effect on TGF-beta2 expression. Fluid streaming rather than thermal effects or cavitation was found to be the most likely explanation for the gene responses observed in vitro.

Viewing alternatives

Look up in Google Scholar

Download history

Item Actions

Export

About

CORE (COnnecting REpositories)

Recommendations