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Smart SU-8 Pillars Implemented in a Microfluidic Bioreactor for Continuous Measurement of Glucose

Talaei, S.; Frey, O.; Psoma, S.; van der Wal, P. D. and de Rooij, N. F (2010). Smart SU-8 Pillars Implemented in a Microfluidic Bioreactor for Continuous Measurement of Glucose. Procedia Engineering, 5 pp. 448–451.

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In this contribution we explore a new and simple approach for immobilizing enzymes like glucose oxidase on SU-8 surfaces to develop a smart substrate integrated in microfluidics. SU-8 is a well known photoresist often used in microfluidic prototyping. Immobilization of enzymes on such substance can open new possibilities in the microfabrication of enzyme biosensors and bioreactors. To demonstrate the consistency of this approach, we describe the design, fabrication and the simple functionalization of a microfluidic bioreactor employing smart SU-8 pillars for continuous amperometric measurement of glucose. The results reveal the possibility of simply binding enzymes on SU-8 surface. Moreover, a significant improvement in the linear response range is observed compared to the previous published amperometric microfluidic glucose sensors.

Item Type: Journal Item
Copyright Holders: 2010 Elsevier Ltd.
ISSN: 1877-7058
Keywords: bioreactor; enzyme; glucose measurement; glucose oxidase; microfabrication; microfluidics; smart substrate; SU-8
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Research Group: Smart Materials
Item ID: 60033
Depositing User: Sotiria Psoma
Date Deposited: 26 Mar 2019 13:52
Last Modified: 05 Apr 2019 04:57
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