An alkylation route to carbo- and heteroaromatic amino acids

Jones, Raymond C.F.; Berthelot, Didier J.C. and Iley, James N. (2007). An alkylation route to carbo- and heteroaromatic amino acids. ARKIVOC(XI) pp. 73–84.

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Abstract

Amino acids carrying aromatic carbo- and heterocycles in the side chain, such as naphthyl-, biphenyl- and pyridylalanines, have been prepared by alkylation of a glycine enolate with a haloalkyl carbocycle or heterocycle, with enantiomeric excess up to 87% using the ephedrine amide protocol.

Item Type:	Journal Article
ISSN:	1424-6376
Keywords:	Amino acid, non-proteinogenic, ephedrine glycinamide, glycine enolate, pyridylalanine
Academic Unit/Department:	Science > Life, Health and Chemical Sciences
Item ID:	5974
Depositing User:	James Iley
Date Deposited:	04 Dec 2006
Last Modified:	05 Dec 2010 06:55
URI:	http://oro.open.ac.uk/id/eprint/5974

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