The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study

Frank, Bernd; Rigas, Sushila H.; Bermejo, Justo Lorenzo; Wiestler, Miriam; Wagner, Kerstin; Hemminki, Kari; Reed, Malcolm W.; Sutter, Christian; Wappenschmidt, Barbara; Balasubramanian, Sabapathy P.; Meindl, Alfons; Kiechle, Marion; Bugert, Peter; Schmutzler, Rita K.; Bartram, Claus R.; Justenhoven, Christina; Ko, Yon-Dschun; Brüning, Thomas; Brauch, Hiltrud; Hamann, Ute; Pharoah, Paul P. D.; Dunning, Alison M.; Pooley, Karen A.; Easton, Douglas F.; Cox, Angela and Burwinkel, Barbara (2008). The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study. Breast Cancer Research and Treatment, 111(1) pp. 139–144.

DOI: https://doi.org/10.1007/s10549-007-9752-z

Abstract

A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.

Viewing alternatives

Look up in Google Scholar

Metrics

Public Attention

Altmetrics from Altmetric

Number of Citations

Citations from Dimensions
No digital document available to download for this item

Item Actions

Export

About

CORE (COnnecting REpositories)

Recommendations