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Identification of a conserved, orphan G-protein coupled receptor required for efficient pathogen clearance in C. elegans

Anderson, Alexandra; Chew, Yee Lian; Schafer, William and Mcmullan, Rachel (2019). Identification of a conserved, orphan G-protein coupled receptor required for efficient pathogen clearance in C. elegans. Infection and immunity, 87(4)

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DOI (Digital Object Identifier) Link: https://doi.org/10.1128/IAI.00034-19
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Abstract

G-protein coupled receptors contribute to host defense across the animal kingdom, transducing many signals involved in both vertebrate and invertebrate immune responses. Whilst it has become well established that the nematode worm Caenorhabditis elegans triggers innate immune responses following infection with numerous bacterial, fungal and viral pathogens, the mechanisms by which C. elegans recognises these pathogens have remained somewhat more elusive. C. elegans G-protein coupled receptors have been implicated in recognising pathogen-associated damage and activating downstream host immune responses. Here we identify and characterise a novel G-protein coupled receptor required to regulate the C. elegans response to infection with Microbacterium nematophilum. We show that this receptor, which we designate PCDR-1, is required for efficient pathogen clearance following infection. PCDR-1 acts upstream of multiple G-proteins including the C. elegans Gαq ortholog EGL-30 in rectal epithelial cells to promote pathogen clearance via a novel mechanism.

Item Type: Journal Item
Copyright Holders: 2019 American Society for Microbiology
ISSN: 1098-5522
Project Funding Details:
Funded Project NameProject IDFunding Body
Genetic analysis of post-developmental Rho GTPase signaling: identification and characterization of Rho signaling pathways required during the C. elegans immune response. (Transfer In)088409/B/09/ZWellcome Trust
Wellcome Trust career development fellowshipWT088409AIAWellcome Trust
Not SetMC-A023-5PB91Medical Research Council
EMBO long-term fellowshipALTF 403-2016EMBO
NIH Office of Research Infrastructure ProgramsP40 OD010440National Institute of Health
Keywords: Caenorhabditis elegans; pathogen clearance; G-protein coupled receptor; Microbacterium nematophilum
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 58675
Depositing User: Rachel Mcmullan
Date Deposited: 21 Jan 2019 09:44
Last Modified: 03 May 2019 14:46
URI: http://oro.open.ac.uk/id/eprint/58675
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