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Four Independent Antigenic Determinants on the Capsid polypeptides of Apthovirus

Haresnape, Janet M. and McCahon, David (1983). Four Independent Antigenic Determinants on the Capsid polypeptides of Apthovirus. Journal of General Virology, 64(11) pp. 2345–2355.

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Four independent antigenic determinants in the virus capsid have been defined in radioimmunoassay tests using antisera prepared against isolated structural polypeptides VP1, 2 and 3. Only one determinant was detected on the intact particle and it was contained within VP1 (called the VP1-A determinant). Three determinants were found on the 12S subparticle, two contained within VP1 (VP1-A and VP1-B determinants) and one contained within VP2 (VP2 determinant). The fourth determinant was contained within VP3 (VP3 determinant) and could only be detected when the virus was disrupted to individual polypeptides. It is concluded that the VP1-A determinant is likely to be of epidemiological importance since (i) it was present on the intact virion, (ii) variation at this determinant was detected with heterologous field strains, (iii) it contained a determinant responsible for the induction of neutralizing antibodies and (iv) it was an antigenic component of the trypsin-sensitive region of VP1 which has been shown previously by several workers to be of critical importance in the immunogenicity of the virus.

Item Type: Journal Item
Copyright Holders: 1983 Society for General Microbiology
ISSN: 1465-2099
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetAgricultural Research Council
Extra Information: This work was undertaken when I was a PhD student, in receipt of a grant from the Agricultural Research Council
Keywords: aphthovirus; foot and mouth disease virus; FMDV; radioimmunoassay; antigenic determinant
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 57974
Depositing User: Janet Haresnape
Date Deposited: 04 Dec 2018 15:10
Last Modified: 01 Apr 2019 21:46
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