The Open UniversitySkip to content
 

The role of N-nitrosation in colon carcinogenesis: some recent insights

Shuker, D.E.G. (2003). The role of N-nitrosation in colon carcinogenesis: some recent insights. In: Scheppach, W and Scheurlen, M eds. Exogenous Factors in Colonic Carcinogenesis. Falk Symposium Series, 128 (128). Wurburg, Germany: Springer, pp. 216–214.

URL: http://www.springer.com/uk/home?SGWID=3-102-22-335...
Google Scholar: Look up in Google Scholar

Abstract

About the book: This book is the proceedings of Falk Symposium 128, held in Würzburg, Germany, on May 2-3, 2002, and dedicated to the important issue of colonic carcinogenesis and its underlying genetic and environmental factors.
Colorectal cancer is one of the leading causes of cancer-related death in industrialized countries. It has been recognized to be the consequence of a dynamic process leading from hyperproliferative epithelium through different classes of adenomas to invasive carcinoma. This adenoma-carcinoma sequence has been characterized on a molecular basis. Modern molecular biology has also helped to clarify the clustering of colorectal cancer within families, a phenomenon that has been known to clinicians for a long time. Thus, the pathogenesis of the two distinct familial colon cancer syndromes FAP (familial adenomatous polyposis) and HNPCC (hereditary non-polyposis colorectal cancer) is increasingly being understood. Thereby, an identification of affected people has become possible before the disease has manifested.
There is also convincing evidence that the pathogenesis of sporadic colonic cancer is modulated by environmental, mainly nutritional, factors. Carcinogens seem to be far less important than the components of the `normal' human diet. It is likely that the interplay between protective and noxious dietary compounds determines the progression of the adenoma-carcinoma sequence. Additionally, a broad spectrum of drugs has been shown to affect colonic tumorigenesis, which provides the rationale for chemoprevention strategies. These issues set the scene for discussions on how genetic and environmental factors may interact in the pathogenesis of colonic cancer, contributing fresh ideas to the prevention of this most prevalent malignancy in the industrialized world.

Item Type: Book Chapter
ISBN: 0-7923-8780-5, 978-0-7923-8780-0
Extra Information: The chapter in question is Chapter 22.
Keywords: glycine derivatives; amines; large bowel; DNA damage; meat;
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Item ID: 5782
Depositing User: David Shuker
Date Deposited: 09 Nov 2006
Last Modified: 02 Dec 2010 19:54
URI: http://oro.open.ac.uk/id/eprint/5782
Share this page:

Actions (login may be required)

View Item
Report issue / request change

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk