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Communication: Site-selective bond excision of adenine upon electron transfer

Cunha, T.; Mendes, M.; Ferreira da Silva, F.; Eden, S.; García, G. and Limão-Vieira, P. (2018). Communication: Site-selective bond excision of adenine upon electron transfer. Journal of Chemical Physics, 148(2), article no. 021101.

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This work demonstrates that selective excision of hydrogen atoms at a particular site of the DNA base adenine can be achieved in collisions with electronegative atoms by controlling the impact energy. The result is based on analysing the time-of-flight mass spectra yields of potassium collisions with a series of labeled adenine derivatives. The production of dehydrogenated parent anions is consistent with neutral H loss either from selective breaking of C–H or N–H bonds. These unprecedented results open up a new methodology in charge transfer collisions that can initiate selective reactivity as a key process in chemical reactions that are dominant in different areas of science and technology.

Item Type: Journal Item
Copyright Holders: 2018 The Authors
ISSN: 1089-7690
Project Funding Details:
Funded Project NameProject IDFunding Body
Electron attachment to biomolecular clusters: probing the role of multiple scattering in radio-sensitivity (SP-10-088-SE)EP/J002577/1EPSRC (Engineering and Physical Sciences Research Council)
Keywords: chemical compounds; mass spectra; hydrogen; collision theories; transition state theory
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Physical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Research Group: Physics
Item ID: 52882
Depositing User: Sam Eden
Date Deposited: 12 Jan 2018 15:11
Last Modified: 12 Sep 2018 05:05
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