Communication: Site-selective bond excision of adenine upon electron transfer

Cunha, T.; Mendes, M.; Ferreira da Silva, F.; Eden, S.; García, G. and Limão-Vieira, P. (2018). Communication: Site-selective bond excision of adenine upon electron transfer. Journal of Chemical Physics, 148(2), article no. 021101.

DOI: https://doi.org/10.1063/1.5018401

Abstract

This work demonstrates that selective excision of hydrogen atoms at a particular site of the DNA base adenine can be achieved in collisions with electronegative atoms by controlling the impact energy. The result is based on analysing the time-of-flight mass spectra yields of potassium collisions with a series of labeled adenine derivatives. The production of dehydrogenated parent anions is consistent with neutral H loss either from selective breaking of C–H or N–H bonds. These unprecedented results open up a new methodology in charge transfer collisions that can initiate selective reactivity as a key process in chemical reactions that are dominant in different areas of science and technology.

Viewing alternatives

Metrics

Item Actions

Export

You can export this page using these formats Digital Object Identifier - DOI

About

• Item ORO ID
• 52882
• Item Type
• Journal Item
• ISSN
• 1089-7690
• Project Funding Details

• Funded Project Name	Project ID	Funding Body
  Electron attachment to biomolecular clusters: probing the role of multiple scattering in radio-sensitivity (SP-10-088-SE)	EP/J002577/1	EPSRC (Engineering and Physical Sciences Research Council)

• Keywords
• chemical compounds; mass spectra; hydrogen; collision theories; transition state theory
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Physical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Research Group
• Physics
• Copyright Holders
• © 2018 The Authors
• Depositing User
• Sam Eden