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Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures

Phillips, Benjamin U.; Lopez-Cruz, Laura; Hailwood, Jonathan; Heath, Christopher J.; Saksida, Lisa M. and Bussey, Timothy J. (2018). Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures. Current Opinion in Behavioral Sciences, 22 pp. 21–27.

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Abstract

A number of neuropsychiatric and neurodegenerative disorders are characterized by motivational impairments manifested as lack of behavioural activation, interest or energy resulting in significant functional impairment. Given the clinical significance of these symptoms, the study of motivation in preclinical research has recently intensified. This review briefly summarises the tasks that have been successfully implemented for the evaluation of motivation in different species, emphasizing the recent use of touchscreen-based rodent testing systems. The touchscreen methodology has been widely used in the evaluation of multiple cognitive domains emphasizing their translational value and flexibility. Recently touchscreen-based versions of classical tasks for the evaluation of motivation have been or are currently being developed and validated, thus facilitating translation from animal to human research and promoting their implementation in clinical contexts.

Item Type: Journal Item
Copyright Holders: 2017 Elsevier Ltd
ISSN: 2352-1546
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNC/N001451/1NC3Rs
Keywords: effort; apathy; anergia; decision making; translational studies; depression; mood
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 52724
Depositing User: Christopher Heath
Date Deposited: 21 Dec 2017 11:59
Last Modified: 20 Oct 2018 05:46
URI: http://oro.open.ac.uk/id/eprint/52724
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