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Elevated expression of a pharmacologic Polycomb signature predicts poor prognosis in gastric and breast cancer

Clermont, Pier-Luc; Fornaro, Lorenzo and Crea, Francesco (2017). Elevated expression of a pharmacologic Polycomb signature predicts poor prognosis in gastric and breast cancer. Epigenomics (Early Access).

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DOI (Digital Object Identifier) Link: https://doi.org/10.2217/epi-2017-0074
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Abstract

Aim: Polycomb Group complexes are epigenetic repressors that silence tumor suppressive genes. Studies demonstrated that pharmacologic inhibition of Polycomb Group complexes with 3-deazaneplanocin A (DZNeP) induces cancer cell death by re-expressing silenced genes. Here we evaluate the prognostic significance of DZNeP target genes in gastric and breast cancer. Patients & methods/materials: The prognostic impact of a DZNeP-regulated gene signature was investigated using the KM Plotter and cBio Portal resources containing microarray data from tumor tissue. Results: We report that elevated expression of DZNeP targets is associated with poor clinical outcome in gastric and breast cancer. In gastric cancer, elevated expression of DZNeP signature is inversely correlated with decreased overall survival. In breast cancer, DZNeP signature predicted poor prognosis in HER2+ tumors but not in HER2- neoplasms. Conclusion: These findings demonstrate that DZNeP target genes are not predictive of better but rather of poor clinical outcome in gastric and breast cancer.

Item Type: Journal Item
Copyright Holders: 2017 Future Medicine
ISSN: 1750-192X
Keywords: cancer; DZNeP; epigenetics; EZH2; Polycomb; prognostic; signature
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Research Group: Health and Wellbeing PRA (Priority Research Area)
Item ID: 50943
Depositing User: Francesco Crea
Date Deposited: 15 Sep 2017 15:16
Last Modified: 15 Sep 2017 15:16
URI: http://oro.open.ac.uk/id/eprint/50943
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