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Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation

Fornaro, Lorenzo; Vivaldi, Caterina; Lin, Dong; Xue, Hui; Falcone, Alfredo; Wang, Yuzhuo; Crea, Francesco and Bootman, Martin D. (2017). Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation. PLoS ONE, 12(8), article no. e0182818.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1371/journal.pone.0182818
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Abstract

Background

T-type calcium channels (TTCCs) mediate calcium influx across the cell membrane. TTCCs regulate numerous physiological processes including cardiac pacemaking and neuronal activity. In addition, they have been implicated in the proliferation, migration and differentiation of tumour tissues. Although the signalling events downstream of TTCC-mediated calcium influx are not fully elucidated, it is clear that variations in the expression of TTCCs promote tumour formation and hinder response to treatment.

Methods

We examined the expression of TTCC genes (all three subtypes; CACNA-1G, CACNA-1H and CACNA-1I) and their prognostic value in three major solid tumours (i.e. gastric, lung and ovarian cancers) via a publicly accessible database.

Results

In gastric cancer, expression of all the CACNA genes was associated with overall survival (OS) among stage I-IV patients (all p<0.05). By combining the three potential biomarkers, a TTCC signature was developed, which retained a significant association with OS both in stage IV and stage I-III patients. In lung and ovarian cancer, association with OS was also significant when all tumour stages were considered, but was partly lost or inconclusive after splitting cases into localized and metastatic subsets.

Conclusions

Alterations in CACNA gene expression are linked to tumour prognosis. Gastric cancer represents the most promising setting for further evaluation.

Item Type: Journal Item
Copyright Holders: 2017 The Authors
ISSN: 1932-6203
Extra Information: Editor: Robert M Lafrenie, Sudbury Regional Hospital, Canada
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Health and Wellbeing PRA (Priority Research Area)
Biomedical Research Network (BRN)
Item ID: 50848
Depositing User: Martin Bootman
Date Deposited: 07 Sep 2017 15:03
Last Modified: 07 Sep 2017 15:03
URI: http://oro.open.ac.uk/id/eprint/50848
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