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Unpredictable saccharin reinforcement enhances locomotor responding to amphetamine

Singer, B. F.; Scott-Railton, J. and Vezina, P. (2012). Unpredictable saccharin reinforcement enhances locomotor responding to amphetamine. Behavioural Brain Research, 226(1) pp. 340–344.

DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.bbr.2011.09.003
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Abstract

Drug-naïve, non-deprived rats were trained to lever press for saccharin under fixed-ratio (FR) or variable-ratio (VR) schedules of reinforcement. Rats trained on the VR schedule in which saccharin reinforcement was not predicted by a fixed number of lever presses subsequently showed an enhanced locomotor response to a threshold amphetamine challenge injection (0.5 mg/kg IP) administered 2 weeks following the last saccharin session. This finding suggests that chronic exposure to gambling-like conditions of uncertain reinforcement can induce neuroadaptations in brain reward systems that are similar to those produced by repeated psychostimulant exposure and may lead to the development of addictive behaviors.

Item Type: Journal Item
Copyright Holders: 2011 Elsevier
ISSN: 1872-7549
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetT32 DA07255US National Institutes of Health (NIH)
Not SetF31 DA030021-01A1US National Institutes of Health (NIH)
Not SetNot SetChicago Biomedical Consortium with support from The Searle Funds at The Chicago Community Trust
Keywords: Addiction; Sensitization; Self-administration; Sucrose; Locomotion
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 50834
Depositing User: Bryan Singer
Date Deposited: 07 Sep 2017 10:21
Last Modified: 11 Dec 2018 11:31
URI: http://oro.open.ac.uk/id/eprint/50834
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