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Inhibiting cyclin-dependent kinase 5 in the nucleus accumbens enhances the expression of amphetamine-induced locomotor conditioning

Singer, B. F.; Forneris, J. and Vezina, P. (2014). Inhibiting cyclin-dependent kinase 5 in the nucleus accumbens enhances the expression of amphetamine-induced locomotor conditioning. Behavioural Brain Research, 275 pp. 96–100.

DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.bbr.2014.08.055
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Abstract

When psychostimulant drugs like amphetamine are administered repeatedly in the presence of a contextual stimulus complex, long-lasting associations form between the unconditioned effects of the drug and the contextual stimuli. Here we assessed the role played by the proline-directed serine/threonine kinase cyclin-dependent kinase 5 (Cdk5) in the nucleus accumbens (NAcc) on the expression of the conditioned locomotion normally observed when rats are returned to a context previously paired with amphetamine. Infusing the Cdk5 inhibitor roscovitine (40 nmol/0.5 μl/side) into the NAcc 30-min before the test for conditioning significantly enhanced the conditioned locomotor response observed in rats previously administered amphetamine in the test environment. This effect was specific to the expression of a conditioned response as inhibiting Cdk5 produced no effect in control rats previously administered saline or previously administered amphetamine elsewhere. As inhibiting Cdk5 during exposure to amphetamine has been found to block the accrual of locomotor conditioning, the present results suggest distinct roles for NAcc Cdk5 in the induction and expression of excitatory conditioning by amphetamine.

Item Type: Journal Item
Copyright Holders: 2014 Elsevier
ISSN: 1872-7549
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetT32 DA07255National Institutes of Health (NIH)
Not SetF31 DA030021-01A1National Institutes of Health (NIH)
Not SetNot SetChicago Biomedical Consortium with support from The Searle Funds at The Chicago Community Trust
Keywords: Cdk5; Conditioning; Learning; Locomotion; Psychostimulants; Roscovitine
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 50830
Depositing User: Bryan Singer
Date Deposited: 06 Sep 2017 15:47
Last Modified: 10 Dec 2018 12:17
URI: http://oro.open.ac.uk/id/eprint/50830
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