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Singer, Bryan F.; Bryan, Myranda A.; Popov, Pavlo; Robinson, Terry E. and Aragona, Brandon J.
(2017).
DOI: https://doi.org/10.1016/j.bbr.2017.02.018
Abstract
Repeated intermittent exposure to cocaine results in the neurochemical sensitization of dopamine (DA) transmission within the nucleus accumbens (NAc). Indeed, the excitability of DA neurons in the ventral tegmental area (VTA) is enhanced within hours of initial psychostimulant exposure. However, it is not known if this is accompanied by a comparably rapid change in the ability of cocaine to increase extracellular DA concentrations in the ventral striatum. To address this question we used fast-scan cyclic voltammetry (FSCV) in awake-behaving rats to measure DA responses in the NAc shell following an initial intravenous cocaine injection, and then again 2-h later. Both injections quickly elevated DA levels in the NAc shell, but the second cocaine infusion produced a greater effect than the first, indicating sensitization. This suggests that a single injection of cocaine induces sensitization-related plasticity very rapidly within the mesolimbic DA system.
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About
- Item ORO ID
- 50825
- Item Type
- Journal Item
- ISSN
- 1872-7549
- Project Funding Details
-
Funded Project Name Project ID Funding Body Not Set P01 DA031656 03 US National Institutes of Health (NIH) Not Set F32 DA038383-01 US National Institutes of Health (NIH) Not Set T32 DA007268-21 US National Institutes of Health (NIH) - Keywords
- Cocaine; Sensitization; Dopamine; Voltammetry; Nucleus accumbens; Psychostimulant
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Copyright Holders
- © 2017 Elsevier
- Depositing User
- Bryan Singer