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Rapid induction of dopamine sensitization in the nucleus accumbens shell induced by a single injection of cocaine

Singer, Bryan F.; Bryan, Myranda A.; Popov, Pavlo; Robinson, Terry E. and Aragona, Brandon J. (2017). Rapid induction of dopamine sensitization in the nucleus accumbens shell induced by a single injection of cocaine. Behavioural Brain Research, 324 pp. 66–70.

DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.bbr.2017.02.018
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Abstract

Repeated intermittent exposure to cocaine results in the neurochemical sensitization of dopamine (DA) transmission within the nucleus accumbens (NAc). Indeed, the excitability of DA neurons in the ventral tegmental area (VTA) is enhanced within hours of initial psychostimulant exposure. However, it is not known if this is accompanied by a comparably rapid change in the ability of cocaine to increase extracellular DA concentrations in the ventral striatum. To address this question we used fast-scan cyclic voltammetry (FSCV) in awake-behaving rats to measure DA responses in the NAc shell following an initial intravenous cocaine injection, and then again 2-h later. Both injections quickly elevated DA levels in the NAc shell, but the second cocaine infusion produced a greater effect than the first, indicating sensitization. This suggests that a single injection of cocaine induces sensitization-related plasticity very rapidly within the mesolimbic DA system.

Item Type: Journal Item
Copyright Holders: 2017 Elsevier
ISSN: 1872-7549
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetP01 DA031656 03US National Institutes of Health (NIH)
Not SetF32 DA038383-01US National Institutes of Health (NIH)
Not SetT32 DA007268-21US National Institutes of Health (NIH)
Keywords: Cocaine; Sensitization; Dopamine; Voltammetry; Nucleus accumbens; Psychostimulant
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 50825
Depositing User: Bryan Singer
Date Deposited: 06 Sep 2017 13:33
Last Modified: 06 May 2019 21:22
URI: http://oro.open.ac.uk/id/eprint/50825
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