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Dissociative multi-photon ionization of isolated uracil and uracil-adenine complexes

Ryszka, M.; Pandey, R.; Rizk, C.; Tabet, J.; Barc, B.; Dampc, M.; Mason, N.J. and Eden, S. (2016). Dissociative multi-photon ionization of isolated uracil and uracil-adenine complexes. International Journal of Mass Spectrometry, 396 pp. 48–54.

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Recent multi-photon ionization (MPI) experiments on uracil revealed a fragment ion at m/z 84 that was proposed as a potential marker for ring opening in the electronically excited neutral molecule. The present MPI measurements on deuterated uracil identify the fragment as C3H4N2O+ (uracil+ less CO), a plausible dissociative ionization product from the theoretically predicted open-ring isomer. Equivalent measurements on thymine do not reveal an analogous CO loss channel, suggesting greater stability of the excited DNA base. MPI and electron impact ionization experiments have been carried out on uracil-adenine clusters in order to better understand the radiation response of uracil within RNA. Evidence for C3H4N2O+ production from multi-photon-ionized uracil-adenine clusters is tentatively attributed to a significant population of π-stacked configurations in the neutral beam.

Item Type: Journal Item
Copyright Holders: 2015 Elsevier
ISSN: 1387-3806
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetThe Open University
Life Sciences Interface FellowshipEP/E039618/1EPSRC (Engineering and Physical Sciences Research Council)
Career Acceleration FellowshipEP/J002577/1EPSRC (Engineering and Physical Sciences Research Council)
Absolute clustering effects on electron attachment (SP-13-004-SE)EP/L002191/1EPSRC (Engineering and Physical Sciences Research Council)
Marie Curie IntraEuropean Reintegration GrantMERG-CT-2007-207292European Commission
Keywords: Uracil; Adenine-uracil clusters; Fragmentation; Multi-photon ionization; Electron impact ionization; Mass spectrometry
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Physical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Research Group: Physics
Item ID: 50513
Depositing User: Sam Eden
Date Deposited: 15 Aug 2017 15:30
Last Modified: 11 Jun 2020 19:43
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